SLC7A8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070327Biological processthyroid hormone transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0015804Biological processneutral amino acid transport
GO_0089718Biological processamino acid import across plasma membrane
GO_0015829Biological processvaline transport
GO_0015816Biological processglycine transport
GO_0003333Biological processamino acid transmembrane transport
GO_0006865Biological processamino acid transport
GO_0035524Biological processproline transmembrane transport
GO_1903801Biological processL-leucine import across plasma membrane
GO_1904273Biological processL-alanine import across plasma membrane
GO_0015827Biological processtryptophan transport
GO_0015820Biological processL-leucine transport
GO_0016323Cellular componentbasolateral plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0031528Cellular componentmicrovillus membrane
GO_0009925Cellular componentbasal plasma membrane
GO_0015171Molecular functionamino acid transmembrane transporter activity
GO_0015179Molecular functionL-amino acid transmembrane transporter activity
GO_0015349Molecular functionthyroid hormone transmembrane transporter activity
GO_0015101Molecular functionorganic cation transmembrane transporter activity
GO_0015180Molecular functionL-alanine transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0019534Molecular functiontoxin transmembrane transporter activity
GO_0015175Molecular functionneutral L-amino acid transmembrane transporter activity
GO_0042605Molecular functionpeptide antigen binding
GO_0015187Molecular functionglycine transmembrane transporter activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0015190Molecular functionL-leucine transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC7A8
Protein nameLarge neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8)
Solute carrier family 7 member 8
SynonymsLAT2
DescriptionFUNCTION: Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids . Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter . This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake . May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney . Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity . Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane . Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (By similarity). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (By similarity). .

AccessionsENST00000422941.6 [Q9UHI5-3]
ENST00000529705.6 [Q9UHI5-4]
E9PIC3
ENST00000524758.1
E9PQT4
ENST00000528860.5
Q9UHI5
ENST00000525062.1
ENST00000339733.9
ENST00000453702.5 [Q9UHI5-2]
ENST00000316902.12 [Q9UHI5-1]
H0Y2X7
ENST00000469263.5
E9PS92
E9PLV9