SLC7A7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903826Biological processL-arginine transmembrane transport
GO_0000821Biological processregulation of arginine metabolic process
GO_1990822Biological processbasic amino acid transmembrane transport
GO_0003333Biological processamino acid transmembrane transport
GO_0015820Biological processL-leucine transport
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0061459Molecular functionL-arginine transmembrane transporter activity
GO_0015179Molecular functionL-amino acid transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0015174Molecular functionbasic amino acid transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC7A7
Protein nameY+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1)
Solute carrier family 7 member 7 isoform 3
Solute carrier family 7 member 7 isoform 4
Y+L amino acid transporter 1
Solute carrier family 7 member 7
Solute carrier family 7 member 7 isoform 1
Synonyms
DescriptionFUNCTION: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine . Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells . The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity). .

AccessionsENST00000698939.1
G3V2K0
G3V4U1
ENST00000556287.5
ENST00000555959.1
G3V2H8
ENST00000556350.1
D6RFE5
ENST00000397528.8
G3V5W2
G3V2L0
G3V4Z6
G3V362
G3V5A1
ENST00000554758.1
ENST00000397529.6
ENST00000555911.1
ENST00000555911.2
ENST00000488800.5
A0A8V8TP95
ENST00000554517.5
G3V273
ENST00000285850.11
H0YJ95
A0A0S2Z4W9
ENST00000555702.5
ENST00000557629.5
ENST00000555251.1
A0A0S2Z502
A0A0S2Z4V9
ENST00000554741.5
ENST00000557129.5
Q9UM01
ENST00000397532.9
ENST00000674313.1