SLC7A10 | OmnibusX

Name	Number of supported studies	Average coverage
adipocyte	6 studies	29% ± 14%	Explore
astrocyte	3 studies	25% ± 6%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC7A10 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	91%	882.90	2415 / 2642	43%	4.44	306 / 705
adipose	96%	2677.60	1156 / 1204	0%	0	0 / 0
breast	71%	1569.11	326 / 459	23%	0.81	255 / 1118
thymus	22%	45.01	146 / 653	16%	0.52	96 / 605
ovary	0%	0	0 / 180	28%	1.39	121 / 430
lung	0%	0	0 / 578	23%	2.02	270 / 1155
bladder	10%	23.29	2 / 21	12%	0.37	62 / 504
kidney	11%	57.24	10 / 89	4%	0.17	36 / 901
uterus	0%	0	0 / 170	14%	2.66	65 / 459
liver	0%	0	0 / 226	13%	2.59	52 / 406
eye	0%	0	0 / 0	13%	0.20	10 / 80
stomach	2%	11.26	6 / 359	10%	1.11	29 / 286
lymph node	0%	0	0 / 0	10%	0.64	3 / 29
esophagus	2%	11.61	36 / 1445	8%	0.79	14 / 183
pancreas	1%	1.35	3 / 328	9%	0.31	16 / 178
skin	3%	8.50	49 / 1809	7%	0.51	33 / 472
adrenal gland	7%	27.20	19 / 258	1%	0.05	3 / 230
blood vessel	8%	44.73	112 / 1335	0%	0	0 / 0
intestine	3%	17.83	29 / 966	5%	0.55	25 / 527
tonsil	0%	0	0 / 0	7%	0.21	3 / 45
heart	2%	5.96	20 / 861	0%	0	0 / 0
muscle	2%	3.89	14 / 803	0%	0	0 / 0
prostate	0%	2.85	1 / 245	0%	0.01	2 / 502
peripheral blood	1%	1.11	6 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0015825	Biological process	L-serine transport
GO_0060094	Biological process	positive regulation of synaptic transmission, glycinergic
GO_0006865	Biological process	amino acid transport
GO_0015804	Biological process	neutral amino acid transport
GO_1903444	Biological process	negative regulation of brown fat cell differentiation
GO_0042942	Biological process	D-serine transmembrane transport
GO_0042941	Biological process	D-alanine transmembrane transport
GO_0015816	Biological process	glycine transport
GO_0003333	Biological process	amino acid transmembrane transport
GO_1902475	Biological process	L-alpha-amino acid transmembrane transport
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0015175	Molecular function	neutral L-amino acid transmembrane transporter activity
GO_0015179	Molecular function	L-amino acid transmembrane transporter activity
GO_0015194	Molecular function	L-serine transmembrane transporter activity
GO_0005515	Molecular function	protein binding

Gene name	SLC7A10
Protein name	Asc-type amino acid transporter 1 (Asc-1) (Solute carrier family 7 member 10) Solute carrier family 7 member 10
Synonyms	ASC1
Description	FUNCTION: Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (By similarity) . Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (By similarity). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (By similarity). May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (By similarity). .
Accessions	ENST00000590036.5 ENST00000592596.1 K7EK24 ENST00000253188.8 K7ENB6 ENST00000587064.5 Q9NS82

SLC7A10 report