SLC5A6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLC5A6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC5A6 at tissue level.

III. Associated gene sets

GO_1905135Biological processbiotin import across plasma membrane
GO_1904200Biological processiodide transmembrane transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0006768Biological processbiotin metabolic process
GO_0015878Biological processbiotin transport
GO_0015887Biological processpantothenate transmembrane transport
GO_0006814Biological processsodium ion transport
GO_0098719Biological processsodium ion import across plasma membrane
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0009925Cellular componentbasal plasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0015233Molecular functionpantothenate transmembrane transporter activity
GO_0015225Molecular functionbiotin transmembrane transporter activity
GO_0090482Molecular functionvitamin transmembrane transporter activity
GO_0008523Molecular functionsodium-dependent multivitamin transmembrane transporter activity
GO_0015498Molecular functionpantothenate:sodium symporter activity
GO_0015111Molecular functioniodide transmembrane transporter activity
GO_0140161Molecular functionmonocarboxylate:sodium symporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC5A6
Protein nameSodium-dependent multivitamin transporter (Solute carrier family 5 member 6)
Solute carrier family 5 member 6
Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6)
Solute carrier family 5 (Sodium-dependent vitamin transporter), member 6, isoform CRA_b (cDNA FLJ14949 fis, clone PLACE2000341, highly similar to Sodium-dependent multivitamin transporter)
SynonymsSMVT
hCG_23723
DescriptionFUNCTION: Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide . Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake . Required for biotin and pantothenate uptake in the intestine across the brush border membrane . Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier . .

AccessionsE7EW78
ENST00000428518.5
ENST00000401463.5
ENST00000442731.1
ENST00000445802.5
E7EMX0
ENST00000432106.5
B3KNM2
ENST00000414408.5
E7ENN0
E7ENG0
Q9Y289
ENST00000426119.5
E7EP02
ENST00000412471.5
ENST00000408041.5
E7ERE1
ENST00000430186.5
Q9HD19
E7EXC0
ENST00000310574.8
E7EW41