SLC5A2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC5A2 at tissue level.

III. Associated gene sets

GO_0005975Biological processcarbohydrate metabolic process
GO_0000017Biological processalpha-glucoside transport
GO_0008645Biological processhexose transmembrane transport
GO_0035623Biological processrenal glucose absorption
GO_0006814Biological processsodium ion transport
GO_0098708Biological processglucose import across plasma membrane
GO_0098719Biological processsodium ion import across plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0055056Molecular functionD-glucose transmembrane transporter activity
GO_0005362Molecular functionlow-affinity glucose:sodium symporter activity
GO_0005412Molecular functionglucose:sodium symporter activity
GO_0015151Molecular functionalpha-glucoside transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC5A2
Protein nameSodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2)
Solute carrier family 5 member 2
Sodium/glucose cotransporter
SynonymsSGLT2
hCG_201215
DescriptionFUNCTION: Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump . Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity). .

AccessionsENST00000330498.4 [P31639-1]
ENST00000419665.6 [P31639-2]
Q8WY15
P31639
H3BP44
ENST00000569576.5