I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| erythrocyte | 13 studies | 58% ± 19% | |
| renal alpha-intercalated cell | 6 studies | 68% ± 22% | |
| erythroblast | 4 studies | 52% ± 25% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| erythrocyte | 13 studies | 58% ± 19% | |
| renal alpha-intercalated cell | 6 studies | 68% ± 22% | |
| erythroblast | 4 studies | 52% ± 25% |
Insufficient scRNA-seq data for expression of SLC4A1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 7120.56 | 89 / 89 | 22% | 41.57 | 194 / 901 |
| spleen | 98% | 2012.44 | 235 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 82% | 12971.98 | 760 / 929 | 0% | 0 | 0 / 0 |
| lung | 78% | 317.97 | 450 / 578 | 1% | 0.05 | 13 / 1155 |
| liver | 70% | 167.90 | 159 / 226 | 1% | 0.11 | 6 / 406 |
| brain | 54% | 51.76 | 1414 / 2642 | 2% | 0.06 | 17 / 705 |
| thymus | 49% | 56.00 | 319 / 653 | 2% | 0.03 | 11 / 605 |
| heart | 41% | 49.44 | 352 / 861 | 0% | 0 | 0 / 0 |
| adipose | 35% | 49.78 | 425 / 1204 | 0% | 0 | 0 / 0 |
| breast | 26% | 25.17 | 121 / 459 | 1% | 0.02 | 8 / 1118 |
| adrenal gland | 12% | 8.78 | 31 / 258 | 8% | 0.95 | 19 / 230 |
| blood vessel | 19% | 16.36 | 252 / 1335 | 0% | 0 | 0 / 0 |
| uterus | 17% | 10.41 | 29 / 170 | 1% | 0.03 | 5 / 459 |
| esophagus | 17% | 15.31 | 239 / 1445 | 1% | 0.03 | 2 / 183 |
| prostate | 16% | 9.35 | 39 / 245 | 0% | 0.00 | 1 / 502 |
| bladder | 14% | 9.33 | 3 / 21 | 1% | 0.01 | 3 / 504 |
| ovary | 13% | 11.23 | 23 / 180 | 1% | 0.01 | 3 / 430 |
| muscle | 13% | 7.34 | 105 / 803 | 0% | 0 | 0 / 0 |
| skin | 12% | 8.82 | 211 / 1809 | 1% | 0.03 | 6 / 472 |
| intestine | 10% | 6.03 | 97 / 966 | 1% | 0.02 | 4 / 527 |
| stomach | 6% | 3.45 | 22 / 359 | 3% | 0.04 | 9 / 286 |
| pancreas | 3% | 1.66 | 11 / 328 | 1% | 0.01 | 1 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.03 | 1 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0048821 | Biological process | erythrocyte development |
| GO_1904539 | Biological process | negative regulation of glycolytic process through fructose-6-phosphate |
| GO_0072659 | Biological process | protein localization to plasma membrane |
| GO_0006821 | Biological process | chloride transport |
| GO_0006873 | Biological process | intracellular monoatomic ion homeostasis |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0045852 | Biological process | pH elevation |
| GO_0007596 | Biological process | blood coagulation |
| GO_0035811 | Biological process | negative regulation of urine volume |
| GO_0006820 | Biological process | monoatomic anion transport |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0017121 | Biological process | plasma membrane phospholipid scrambling |
| GO_0051453 | Biological process | regulation of intracellular pH |
| GO_0015701 | Biological process | bicarbonate transport |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0030018 | Cellular component | Z disc |
| GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0072562 | Cellular component | blood microparticle |
| GO_0030863 | Cellular component | cortical cytoskeleton |
| GO_0170014 | Cellular component | ankyrin-1 complex |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0043495 | Molecular function | protein-membrane adaptor activity |
| GO_0008509 | Molecular function | monoatomic anion transmembrane transporter activity |
| GO_0015106 | Molecular function | bicarbonate transmembrane transporter activity |
| GO_0015108 | Molecular function | chloride transmembrane transporter activity |
| GO_0140900 | Molecular function | chloride:bicarbonate antiporter activity |
| GO_0030506 | Molecular function | ankyrin binding |
| GO_0005452 | Molecular function | solute:inorganic anion antiporter activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0030492 | Molecular function | hemoglobin binding |
| Gene name | SLC4A1 |
| Protein name | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) Solute carrier family 4 member 1 (Diego blood group) Anion exchange protein Anion exchange protein 1 Band 3 anion exchanger Band 3 anion transport protein |
| Synonyms | EPB3 AE1 DI |
| Description | FUNCTION: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein . Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin . Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine . .; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes . Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes . . |
| Accessions | ENST00000262418.12 [P02730-1] A0A173G8H7 P02730 ENST00000399246.3 E2RVJ0 A0A0H3YPP8 A0A173G4C3 A0A346REW0 A0A346REB3 E2J829 E2J824 A0A346RF06 A0A0A0MS98 |
