I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell of proximal tubule | 4 studies | 29% ± 9% | |
| GABAergic neuron | 3 studies | 22% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell of proximal tubule | 4 studies | 29% ± 9% | |
| GABAergic neuron | 3 studies | 22% ± 5% |
Insufficient scRNA-seq data for expression of SLC47A1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 98% | 659.45 | 640 / 653 | 91% | 18.98 | 550 / 605 |
| liver | 100% | 5567.21 | 226 / 226 | 88% | 42.74 | 359 / 406 |
| kidney | 100% | 4774.33 | 89 / 89 | 85% | 107.31 | 763 / 901 |
| adrenal gland | 100% | 15298.74 | 258 / 258 | 47% | 30.64 | 108 / 230 |
| lung | 85% | 512.89 | 493 / 578 | 35% | 5.05 | 399 / 1155 |
| uterus | 100% | 1662.99 | 170 / 170 | 17% | 4.18 | 80 / 459 |
| muscle | 100% | 2698.31 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 98% | 486.59 | 236 / 241 | 0% | 0 | 0 / 0 |
| prostate | 95% | 877.12 | 233 / 245 | 2% | 0.13 | 9 / 502 |
| skin | 77% | 835.77 | 1386 / 1809 | 20% | 2.00 | 95 / 472 |
| ovary | 92% | 958.81 | 166 / 180 | 3% | 0.45 | 13 / 430 |
| blood vessel | 87% | 562.40 | 1164 / 1335 | 0% | 0 | 0 / 0 |
| brain | 54% | 260.04 | 1428 / 2642 | 19% | 2.04 | 136 / 705 |
| breast | 41% | 122.98 | 190 / 459 | 8% | 1.04 | 86 / 1118 |
| intestine | 48% | 163.22 | 459 / 966 | 1% | 0.09 | 5 / 527 |
| heart | 43% | 225.13 | 367 / 861 | 0% | 0 | 0 / 0 |
| adipose | 42% | 135.88 | 506 / 1204 | 0% | 0 | 0 / 0 |
| esophagus | 18% | 53.27 | 260 / 1445 | 19% | 1.91 | 34 / 183 |
| stomach | 23% | 96.46 | 84 / 359 | 3% | 0.42 | 10 / 286 |
| bladder | 14% | 47.95 | 3 / 21 | 6% | 1.00 | 32 / 504 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 1.00 | 4 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 0.91 | 6 / 45 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.64 | 7 / 80 |
| peripheral blood | 7% | 39.31 | 67 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0 | 0 / 328 | 2% | 0.40 | 3 / 178 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0015695 | Biological process | organic cation transport |
| GO_0006855 | Biological process | xenobiotic transmembrane transport |
| GO_0015847 | Biological process | putrescine transport |
| GO_0055085 | Biological process | transmembrane transport |
| GO_1990961 | Biological process | xenobiotic detoxification by transmembrane export across the plasma membrane |
| GO_1903826 | Biological process | L-arginine transmembrane transport |
| GO_0071934 | Biological process | thiamine transmembrane transport |
| GO_0042908 | Biological process | xenobiotic transport |
| GO_0089718 | Biological process | amino acid import across plasma membrane |
| GO_1902475 | Biological process | L-alpha-amino acid transmembrane transport |
| GO_0097638 | Biological process | L-arginine import across plasma membrane |
| GO_1902600 | Biological process | proton transmembrane transport |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0061459 | Molecular function | L-arginine transmembrane transporter activity |
| GO_0015179 | Molecular function | L-amino acid transmembrane transporter activity |
| GO_0140968 | Molecular function | polyspecific organic cation:proton antiporter activity |
| GO_0015489 | Molecular function | putrescine transmembrane transporter activity |
| GO_0015101 | Molecular function | organic cation transmembrane transporter activity |
| GO_0015297 | Molecular function | antiporter activity |
| GO_0042910 | Molecular function | xenobiotic transmembrane transporter activity |
| GO_0015234 | Molecular function | thiamine transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0022857 | Molecular function | transmembrane transporter activity |
| Gene name | SLC47A1 |
| Protein name | Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1) Multidrug and toxin extrusion protein 1 (Solute carrier family 47 member 1) Solute carrier family 47 member 1 |
| Synonyms | MATE1 |
| Description | FUNCTION: Multidrug efflux pump that functions as a H(+)/organic cation antiporter . Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively . Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate . May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). . |
| Accessions | I3L345 ENST00000571335.5 ENST00000581558.1 ENST00000395585.5 [Q96FL8-3] ENST00000575023.5 J3KRZ3 E7EX57 ENST00000270570.8 [Q96FL8-1] Q96FL8 ENST00000436810.6 J3KSS8 |
