SLC44A4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061526Biological processacetylcholine secretion
GO_0006656Biological processphosphatidylcholine biosynthetic process
GO_0008292Biological processacetylcholine biosynthetic process
GO_0015871Biological processcholine transport
GO_0032475Biological processotolith formation
GO_0030307Biological processpositive regulation of cell growth
GO_0055085Biological processtransmembrane transport
GO_0035675Biological processneuromast hair cell development
GO_0030974Biological processthiamine pyrophosphate transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0090422Molecular functionthiamine pyrophosphate transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0015220Molecular functioncholine transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC44A4
Protein nameCholine transporter-like protein
Choline transporter-like protein 4 (Solute carrier family 44 member 4) (Thiamine pyrophosphate transporter 1) (hTPPT1)
SynonymsNG22
C6orf29
TPPT1
CTL4
UNQ441/PRO874
DescriptionFUNCTION: Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity) . Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis . .; FUNCTION: [Isoform 3]: Has also thiamine pyrophosphate transporter activity. .

FUNCTION: Choline transporter. .

FUNCTION: Choline transporter. .

FUNCTION: Choline transporter. .

AccessionsENST00000414427.1
ENST00000548188.1 [Q53GD3-3]
ENST00000547684.1 [Q53GD3-3]
ENST00000450933.5
ENST00000553121.5
ENST00000550401.2
A0A0G2JL76
ENST00000546461.3 [Q53GD3-3]
ENST00000229729.11 [Q53GD3-1]
A0A0G2JIN1
ENST00000553147.1
ENST00000414684.5
ENST00000458130.5
H0Y5I3
ENST00000549663.5 [Q53GD3-4]
ENST00000433046.5
Q53GD3
ENST00000550821.4
ENST00000544672.5 [Q53GD3-3]
ENST00000551168.3 [Q53GD3-4]
ENST00000549677.5 [Q53GD3-4]
ENST00000383379.8 [Q53GD3-1]
ENST00000442152.6
ENST00000453831.6 [Q53GD3-1]
ENST00000417894.6
ENST00000547493.1
ENST00000441920.5
ENST00000425238.6 [Q53GD3-1]
ENST00000415517.6
ENST00000547288.5
ENST00000431710.5
ENST00000375562.8 [Q53GD3-4]