SLC41A1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC41A1 at tissue level.

III. Associated gene sets

GO_0030001Biological processmetal ion transport
GO_0015693Biological processmagnesium ion transport
GO_0010961Biological processintracellular magnesium ion homeostasis
GO_0035725Biological processsodium ion transmembrane transport
GO_0071286Biological processcellular response to magnesium ion
GO_1903830Biological processmagnesium ion transmembrane transport
GO_0032991Cellular componentprotein-containing complex
GO_0005886Cellular componentplasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0061768Molecular functionmagnesium:sodium antiporter activity
GO_0022890Molecular functioninorganic cation transmembrane transporter activity
GO_0015095Molecular functionmagnesium ion transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC41A1
Protein nameSolute carrier family 41 member 1
Solute carrier family 41 member
SynonymshCG_19155
DescriptionFUNCTION: Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane . Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump . Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day . Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). .

FUNCTION: Acts as a magnesium transporter. .

AccessionsB2RMP2
ENST00000367137.4
Q8IVJ1