SLC3A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990822Biological processbasic amino acid transmembrane transport
GO_0015813Biological processL-glutamate transmembrane transport
GO_0005975Biological processcarbohydrate metabolic process
GO_0015810Biological processaspartate transmembrane transport
GO_0015802Biological processbasic amino acid transport
GO_0015811Biological processL-cystine transport
GO_0010467Biological processgene expression
GO_0006865Biological processamino acid transport
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005774Cellular componentvacuolar membrane
GO_0015171Molecular functionamino acid transmembrane transporter activity
GO_0015174Molecular functionbasic amino acid transmembrane transporter activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0015184Molecular functionL-cystine transmembrane transporter activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC3A1
Protein nameAmino acid transporter heavy chain SLC3A1 (D2h) (Neutral and basic amino acid transport protein) (NBAT) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transporter-related heavy chain) (rBAT)
Solute carrier family 3 (Cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1, isoform CRA_a (Solute carrier family 3 member 1 isoform 1)
Solute carrier family 3 member 1
Solute carrier family 3 member 1 isoform 2
SynonymshCG_16811
NBAT
DescriptionFUNCTION: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane (By similarity). Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules . Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate (By similarity). .

AccessionsENST00000409229.7 [Q07837-6]
ENST00000427285.1
C9JBK3
ENST00000409294.5
A0A0S2Z4D3
ENST00000409741.5 [Q07837-5]
ENST00000410056.7 [Q07837-3]
ENST00000611973.4
Q07837
A0A087X0R9
ENST00000260649.11 [Q07837-1]
A0A0S2Z4E1
B8ZZK1
ENST00000409380.5 [Q07837-2]
B8ZZP2
ENST00000409387.5
ENST00000409740.3 [Q07837-4]