SLC39A8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015694Biological processmercury ion transport
GO_0042391Biological processregulation of membrane potential
GO_0071577Biological processzinc ion transmembrane transport
GO_0098711Biological processiron ion import across plasma membrane
GO_0030026Biological processintracellular manganese ion homeostasis
GO_0030198Biological processextracellular matrix organization
GO_1990079Biological processcartilage homeostasis
GO_0061757Biological processleukocyte adhesion to arterial endothelial cell
GO_0071421Biological processmanganese ion transmembrane transport
GO_0006351Biological processDNA-templated transcription
GO_0050728Biological processnegative regulation of inflammatory response
GO_0006882Biological processintracellular zinc ion homeostasis
GO_0098849Biological processcellular detoxification of cadmium ion
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006525Biological processarginine metabolic process
GO_0006829Biological processzinc ion transport
GO_0030003Biological processintracellular monoatomic cation homeostasis
GO_0071578Biological processzinc ion import across plasma membrane
GO_0006487Biological processprotein N-linked glycosylation
GO_0015701Biological processbicarbonate transport
GO_0097080Biological processplasma membrane selenite transport
GO_1990540Biological processmitochondrial manganese ion transmembrane transport
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0070574Biological processcadmium ion transmembrane transport
GO_0006824Biological processcobalt ion transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0031090Cellular componentorganelle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005385Molecular functionzinc ion transmembrane transporter activity
GO_0140412Molecular functionzinc:bicarbonate symporter activity
GO_0140410Molecular functionmonoatomic cation:bicarbonate symporter activity

IV. Literature review

[source]
Gene nameSLC39A8
Protein nameSolute carrier family 39 member 8
Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8)
SynonymsPP3105
BIGM103
ZIP8
DescriptionFUNCTION: Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity . Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion . Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient . Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic . May also transport iron and cobalt through membranes . Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development . Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization . Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes . Protects, for instance, cells from injury and death at the onset of inflammation . By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient . Also participates in manganese reabsorption in the proximal tubule of the kidney . By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain . With manganese cellular uptake also participates in mitochondrial proper function . Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation . .

AccessionsENST00000683221.1
A0A804HKX2
Q9C0K1
ENST00000683412.1 [Q9C0K1-1]
A0A804HJR0
A0A804HHS9
A0A804HKQ9
ENST00000683634.1
ENST00000683173.1
A0A804HHT0
ENST00000356736.5 [Q9C0K1-1]
ENST00000682932.1 [Q9C0K1-1]
ENST00000682227.1 [Q9C0K1-1]
ENST00000424970.7
ENST00000683462.1
ENST00000682243.1
ENST00000683706.1
ENST00000684386.1
ENST00000683916.1
ENST00000394833.6 [Q9C0K1-1]
A0A804HKW0
ENST00000684289.1
ENST00000682549.1