SLC39A5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030003Biological processintracellular monoatomic cation homeostasis
GO_0030509Biological processBMP signaling pathway
GO_0071578Biological processzinc ion import across plasma membrane
GO_0061351Biological processneural precursor cell proliferation
GO_0015701Biological processbicarbonate transport
GO_0071577Biological processzinc ion transmembrane transport
GO_0048026Biological processpositive regulation of mRNA splicing, via spliceosome
GO_0070315Biological processG1 to G0 transition involved in cell differentiation
GO_0001654Biological processeye development
GO_0034224Biological processcellular response to zinc ion starvation
GO_0006829Biological processzinc ion transport
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005385Molecular functionzinc ion transmembrane transporter activity
GO_0140410Molecular functionmonoatomic cation:bicarbonate symporter activity
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameSLC39A5
Protein nameSolute carrier family 39 member 5
Zinc transporter ZIP5 (Solute carrier family 39 member 5) (Zrt- and Irt-like protein 5) (ZIP-5)
SynonymsZIP5
DescriptionFUNCTION: Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine (By similarity). The transport mechanism is temperature- and concentration-dependent and saturable (By similarity). In addition, is also a high affinity copper transporter in vitro . Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis (By similarity). Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera . Plays a role in eye development . .

AccessionsC9JPS6
ENST00000454355.7
C9JB28
ENST00000417965.5
ENST00000419753.5
C9JIB2
ENST00000424625.5
C9JVC6
C9JPS5
ENST00000266980.8
ENST00000437277.1
Q6ZMH5
ENST00000436633.5