I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 29% ± 9% | |
| plasma cell | 4 studies | 36% ± 10% | |
| plasmablast | 4 studies | 48% ± 21% | |
| fibroblast | 3 studies | 36% ± 3% | |
| erythroblast | 3 studies | 41% ± 20% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 29% ± 9% | |
| plasma cell | 4 studies | 36% ± 10% | |
| plasmablast | 4 studies | 48% ± 21% | |
| fibroblast | 3 studies | 36% ± 3% | |
| erythroblast | 3 studies | 41% ± 20% |
Insufficient scRNA-seq data for expression of SLC38A5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 1379.58 | 2586 / 2642 | 99% | 62.49 | 698 / 705 |
| thymus | 100% | 1810.80 | 650 / 653 | 92% | 74.21 | 559 / 605 |
| pancreas | 100% | 10470.16 | 328 / 328 | 80% | 39.72 | 143 / 178 |
| lung | 100% | 2642.67 | 578 / 578 | 67% | 22.50 | 779 / 1155 |
| stomach | 81% | 1000.77 | 289 / 359 | 63% | 41.73 | 180 / 286 |
| intestine | 56% | 546.02 | 542 / 966 | 75% | 61.07 | 397 / 527 |
| esophagus | 74% | 539.98 | 1068 / 1445 | 56% | 21.95 | 102 / 183 |
| uterus | 65% | 364.28 | 111 / 170 | 62% | 34.92 | 284 / 459 |
| skin | 99% | 2039.53 | 1790 / 1809 | 24% | 5.88 | 113 / 472 |
| ovary | 90% | 774.46 | 162 / 180 | 28% | 6.05 | 120 / 430 |
| bladder | 48% | 615.95 | 10 / 21 | 57% | 35.26 | 288 / 504 |
| ureter | 0% | 0 | 0 / 0 | 100% | 24.97 | 1 / 1 |
| peripheral blood | 100% | 3106.67 | 927 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1572.48 | 240 / 241 | 0% | 0 | 0 / 0 |
| prostate | 84% | 722.67 | 205 / 245 | 2% | 0.29 | 11 / 502 |
| lymph node | 0% | 0 | 0 / 0 | 83% | 30.11 | 24 / 29 |
| breast | 36% | 171.08 | 165 / 459 | 36% | 6.08 | 402 / 1118 |
| tonsil | 0% | 0 | 0 / 0 | 58% | 18.68 | 26 / 45 |
| eye | 0% | 0 | 0 / 0 | 43% | 29.24 | 34 / 80 |
| adipose | 41% | 247.13 | 489 / 1204 | 0% | 0 | 0 / 0 |
| heart | 37% | 255.69 | 321 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 35% | 225.17 | 471 / 1335 | 0% | 0 | 0 / 0 |
| kidney | 19% | 95.34 | 17 / 89 | 14% | 6.63 | 126 / 901 |
| adrenal gland | 16% | 76.47 | 42 / 258 | 4% | 1.21 | 9 / 230 |
| liver | 1% | 6.04 | 3 / 226 | 3% | 1.09 | 14 / 406 |
| muscle | 0% | 0.35 | 1 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0089709 | Biological process | L-histidine transmembrane transport |
| GO_0006867 | Biological process | asparagine transport |
| GO_0032973 | Biological process | amino acid export across plasma membrane |
| GO_1903812 | Biological process | L-serine import across plasma membrane |
| GO_0006868 | Biological process | glutamine transport |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0015804 | Biological process | neutral amino acid transport |
| GO_0089718 | Biological process | amino acid import across plasma membrane |
| GO_0015816 | Biological process | glycine transport |
| GO_1904557 | Biological process | L-alanine transmembrane transport |
| GO_0015825 | Biological process | L-serine transport |
| GO_0006865 | Biological process | amino acid transport |
| GO_1903713 | Biological process | asparagine transmembrane transport |
| GO_1903803 | Biological process | L-glutamine import across plasma membrane |
| GO_0032329 | Biological process | serine transport |
| GO_0035725 | Biological process | sodium ion transmembrane transport |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0015171 | Molecular function | amino acid transmembrane transporter activity |
| GO_0015194 | Molecular function | L-serine transmembrane transporter activity |
| GO_0005290 | Molecular function | L-histidine transmembrane transporter activity |
| GO_0015186 | Molecular function | L-glutamine transmembrane transporter activity |
| GO_0140830 | Molecular function | L-glutamine, sodium:proton antiporter activity |
| GO_0015187 | Molecular function | glycine transmembrane transporter activity |
| GO_0022858 | Molecular function | alanine transmembrane transporter activity |
| GO_0140893 | Molecular function | neutral amino acid, sodium:proton antiporter activity |
| GO_0015182 | Molecular function | L-asparagine transmembrane transporter activity |
| Gene name | SLC38A5 |
| Protein name | Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2) Solute carrier family 38 member 5 |
| Synonyms | SNAT5 PP7194 SN2 JM24 |
| Description | FUNCTION: Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity . Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate-glutamine cycle (By similarity). The transport activity is pH sensitive and Li(+) tolerant . Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity). . |
| Accessions | Q8WUX1 ENST00000494034.5 C9JWG4 C9JHH7 ENST00000619100.4 [Q8WUX1-2] ENST00000620913.5 [Q8WUX1-1] ENST00000413668.5 C9JMY2 ENST00000429543.2 ENST00000441948.5 A0A087WZF9 C9JJU1 ENST00000595796.5 [Q8WUX1-1] C9JNK4 ENST00000440085.5 ENST00000416711.5 ENST00000488083.5 |
