SLC38A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006868Biological processglutamine transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0051365Biological processcellular response to potassium ion starvation
GO_1903811Biological processL-asparagine import across plasma membrane
GO_0007565Biological processfemale pregnancy
GO_0010585Biological processglutamine secretion
GO_0006814Biological processsodium ion transport
GO_0080144Biological processintracellular amino acid homeostasis
GO_0015808Biological processL-alanine transport
GO_0003333Biological processamino acid transmembrane transport
GO_0006865Biological processamino acid transport
GO_2000487Biological processpositive regulation of glutamine transport
GO_0015817Biological processhistidine transport
GO_1903803Biological processL-glutamine import across plasma membrane
GO_1902024Biological processL-histidine transport
GO_0006867Biological processasparagine transport
GO_1903810Biological processL-histidine import across plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0015171Molecular functionamino acid transmembrane transporter activity
GO_0005290Molecular functionL-histidine transmembrane transporter activity
GO_0015180Molecular functionL-alanine transmembrane transporter activity
GO_0015186Molecular functionL-glutamine transmembrane transporter activity
GO_0140830Molecular functionL-glutamine, sodium:proton antiporter activity
GO_0140831Molecular functionL-asparagine, sodium:proton antiporter activity
GO_0140832Molecular functionL-histidine, sodium:proton antiporter activity
GO_0005295Molecular functionneutral L-amino acid:sodium symporter activity
GO_0015182Molecular functionL-asparagine transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC38A3
Protein nameSodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1)
Solute carrier family 38 member 3
SynonymsSNAT3
NAT1
SN1
G17
DescriptionFUNCTION: Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity . Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L-glutamine, L-histidine and L-asparagine . The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions . Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity). .

AccessionsA0A087WVW8
ENST00000621456.2
ENST00000610458.4
A0A087WWS5
A0A087X175
A0A087X1Q4
Q99624
ENST00000614032.5
ENST00000621714.4
ENST00000445096.5