SLC35D3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLC35D3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC35D3 at tissue level.

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0015786Biological processUDP-glucose transmembrane transport
GO_0060155Biological processplatelet dense granule organization
GO_0010508Biological processpositive regulation of autophagy
GO_0032527Biological processprotein exit from endoplasmic reticulum
GO_0055085Biological processtransmembrane transport
GO_0070863Biological processpositive regulation of protein exit from endoplasmic reticulum
GO_0031901Cellular componentearly endosome membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005460Molecular functionUDP-glucose transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity

IV. Literature review

[source]
Gene nameSLC35D3
Protein nameSolute carrier family 35 member D3 (Fringe connection-like protein 1)
SynonymsFRCL1
DescriptionFUNCTION: Probable UDP-glucose transmembrane transporter involved in UDP-glucose transport from the cytosol to the lumen of synaptic vesicles . It is involved in platelet dense granules maturation (By similarity). .; FUNCTION: Alternatively, could function as a molecular adapter enhancing the formation of the PI3KC3-C1/AIC/autophagy initiation complex to promote autophagy in dopaminergic neurons. Could also regulate the plasma membrane localization of the D(1A) dopamine receptor/DRD1 and dopamine signaling. .

AccessionsQ5M8T2
ENST00000331858.5