SLC29A3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC29A3 at tissue level.

III. Associated gene sets

GO_0035340Biological processinosine transport
GO_1904082Biological processpyrimidine nucleobase transmembrane transport
GO_0006805Biological processxenobiotic metabolic process
GO_1904823Biological processpurine nucleobase transmembrane transport
GO_0015861Biological processcytidine transport
GO_0015851Biological processnucleobase transport
GO_0015872Biological processdopamine transport
GO_0015858Biological processnucleoside transport
GO_1903716Biological processguanine transmembrane transport
GO_0006837Biological processserotonin transport
GO_0015862Biological processuridine transmembrane transport
GO_0006836Biological processneurotransmitter transport
GO_0032238Biological processadenosine transport
GO_0015874Biological processnorepinephrine transport
GO_1901642Biological processnucleoside transmembrane transport
GO_1903791Biological processuracil transmembrane transport
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0005794Cellular componentGolgi apparatus
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005765Cellular componentlysosomal membrane
GO_0015205Molecular functionnucleobase transmembrane transporter activity
GO_0015101Molecular functionorganic cation transmembrane transporter activity
GO_0005326Molecular functionneurotransmitter transmembrane transporter activity
GO_0008504Molecular functionmonoamine transmembrane transporter activity
GO_0015210Molecular functionuracil transmembrane transporter activity
GO_0015213Molecular functionuridine transmembrane transporter activity
GO_0015208Molecular functionguanine transmembrane transporter activity
GO_0005337Molecular functionnucleoside transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0015212Molecular functioncytidine transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC29A3
Protein nameSolute carrier family 29 member 3
Equilibrative nucleoside transporter 3 (hENT3) (Solute carrier family 29 member 3)
SynonymsUNQ717/PRO1380
ENT3
DescriptionFUNCTION: Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes . Functions as a non-electrogenic Na(+)-independent transporter . Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments . Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation . May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids . Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine) . Also mediates transport of purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil) . Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine . Capable of transporting ATP . Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers (By similarity). .

AccessionsA0A2R8YDA4
A0A2R8Y4I0
A0A2R8Y657
ENST00000647524.1
ENST00000644088.1
Q9BZD2
ENST00000643619.1
ENST00000642772.1
A0A2R8YDR8
ENST00000642198.1
ENST00000645345.1
ENST00000479577.2
A0A2R8Y4B7
ENST00000644895.1
A0A2R8Y5R8
A0A2R8YGC2
ENST00000373189.6 [Q9BZD2-1]
A0A2R8Y5U2
ENST00000643752.1
ENST00000643042.1
ENST00000644591.1
A0A2R8Y863