SLC25A33 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903426Biological processregulation of reactive oxygen species biosynthetic process
GO_0051881Biological processregulation of mitochondrial membrane potential
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0034551Biological processmitochondrial respiratory chain complex III assembly
GO_1990314Biological processcellular response to insulin-like growth factor stimulus
GO_0007005Biological processmitochondrion organization
GO_0031930Biological processmitochondria-nucleus signaling pathway
GO_0032869Biological processcellular response to insulin stimulus
GO_0000002Biological processmitochondrial genome maintenance
GO_0030307Biological processpositive regulation of cell growth
GO_0006390Biological processmitochondrial transcription
GO_0006864Biological processpyrimidine nucleotide transport
GO_1990519Biological processpyrimidine nucleotide import into mitochondrion
GO_0002082Biological processregulation of oxidative phosphorylation
GO_0031966Cellular componentmitochondrial membrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0015218Molecular functionpyrimidine nucleotide transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC25A33
Protein nameSolute carrier family 25 member 33 (Bone marrow stromal cell mitochondrial carrier protein) (BMSC-MCP) (HuBMSC-MCP) (Protein PNC1)
Synonyms
DescriptionFUNCTION: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism . May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism . Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration . Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production . Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation . .

AccessionsENST00000302692.7
Q9BSK2