SLC25A27 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048839Biological processinner ear development
GO_0051562Biological processnegative regulation of mitochondrial calcium ion concentration
GO_1902476Biological processchloride transmembrane transport
GO_0009409Biological processresponse to cold
GO_0035356Biological processintracellular triglyceride homeostasis
GO_0046324Biological processregulation of glucose import
GO_0010917Biological processnegative regulation of mitochondrial membrane potential
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_1902600Biological processproton transmembrane transport
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0043025Cellular componentneuronal cell body
GO_0005743Cellular componentmitochondrial inner membrane
GO_0045177Cellular componentapical part of cell
GO_0042803Molecular functionprotein homodimerization activity
GO_0015078Molecular functionproton transmembrane transporter activity
GO_0015108Molecular functionchloride transmembrane transporter activity
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC25A27
Protein nameMitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27)
Solute carrier family 25 member 27
Solute carrier family 25, member 27, isoform CRA_a (cDNA FLJ57819, highly similar to Mitochondrial uncoupling protein 4) (cDNA, FLJ78839, highly similar to Mitochondrial uncoupling protein 4)
SynonymsUCP4
UNQ772/PRO1566
hCG_16892
DescriptionFUNCTION: Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated. .

AccessionsENST00000411689.6 [O95847-2]
ENST00000604127.5
Q5VTS8
S4R3J2
ENST00000603486.5
S4R300
B4DHR4
ENST00000604616.1
O95847
ENST00000371347.10 [O95847-1]
ENST00000604217.5