Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte precursor cell | 10 studies | 40% ± 20% | |
oligodendrocyte | 9 studies | 33% ± 13% | |
astrocyte | 8 studies | 34% ± 12% | |
glutamatergic neuron | 6 studies | 45% ± 26% | |
endothelial cell | 6 studies | 31% ± 12% | |
GABAergic neuron | 5 studies | 46% ± 17% | |
interneuron | 5 studies | 36% ± 23% | |
neuron | 3 studies | 29% ± 17% | |
cardiac muscle cell | 3 studies | 19% ± 2% | |
OFF-bipolar cell | 3 studies | 31% ± 16% | |
retinal rod cell | 3 studies | 23% ± 4% | |
adipocyte | 3 studies | 21% ± 2% | |
smooth muscle cell | 3 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 4710.66 | 245 / 245 | 99% | 18.60 | 497 / 502 |
brain | 99% | 3799.39 | 2626 / 2642 | 97% | 23.25 | 682 / 705 |
adrenal gland | 97% | 1436.54 | 250 / 258 | 97% | 14.32 | 222 / 230 |
thymus | 100% | 4662.71 | 653 / 653 | 89% | 10.56 | 538 / 605 |
ovary | 100% | 6140.07 | 180 / 180 | 81% | 6.09 | 348 / 430 |
pancreas | 97% | 1271.16 | 318 / 328 | 84% | 6.90 | 149 / 178 |
intestine | 98% | 2517.53 | 946 / 966 | 76% | 5.02 | 403 / 527 |
uterus | 99% | 4155.33 | 169 / 170 | 75% | 5.39 | 342 / 459 |
kidney | 98% | 2488.25 | 87 / 89 | 76% | 7.53 | 686 / 901 |
esophagus | 94% | 3038.33 | 1352 / 1445 | 72% | 4.48 | 131 / 183 |
skin | 88% | 1684.02 | 1599 / 1809 | 76% | 8.29 | 360 / 472 |
bladder | 100% | 2892.57 | 21 / 21 | 63% | 4.20 | 316 / 504 |
stomach | 92% | 1796.79 | 331 / 359 | 62% | 4.25 | 176 / 286 |
breast | 99% | 2333.59 | 454 / 459 | 52% | 3.23 | 585 / 1118 |
lung | 94% | 1588.76 | 546 / 578 | 55% | 3.19 | 637 / 1155 |
liver | 86% | 1407.12 | 194 / 226 | 51% | 2.80 | 208 / 406 |
blood vessel | 99% | 2144.67 | 1318 / 1335 | 0% | 0 | 0 / 0 |
adipose | 98% | 1914.82 | 1179 / 1204 | 0% | 0 | 0 / 0 |
heart | 89% | 1368.91 | 770 / 861 | 0% | 0 | 0 / 0 |
spleen | 84% | 969.46 | 203 / 241 | 0% | 0 | 0 / 0 |
muscle | 77% | 770.94 | 621 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 42% | 1.64 | 19 / 45 |
eye | 0% | 0 | 0 / 0 | 41% | 3.36 | 33 / 80 |
lymph node | 0% | 0 | 0 / 0 | 17% | 1.13 | 5 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0048839 | Biological process | inner ear development |
GO_0051562 | Biological process | negative regulation of mitochondrial calcium ion concentration |
GO_1902476 | Biological process | chloride transmembrane transport |
GO_0009409 | Biological process | response to cold |
GO_0035356 | Biological process | intracellular triglyceride homeostasis |
GO_0046324 | Biological process | regulation of glucose import |
GO_0010917 | Biological process | negative regulation of mitochondrial membrane potential |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
GO_1902600 | Biological process | proton transmembrane transport |
GO_0005739 | Cellular component | mitochondrion |
GO_0031966 | Cellular component | mitochondrial membrane |
GO_0043025 | Cellular component | neuronal cell body |
GO_0005743 | Cellular component | mitochondrial inner membrane |
GO_0045177 | Cellular component | apical part of cell |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0015078 | Molecular function | proton transmembrane transporter activity |
GO_0015108 | Molecular function | chloride transmembrane transporter activity |
GO_0022857 | Molecular function | transmembrane transporter activity |
Gene name | SLC25A27 |
Protein name | Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27) Solute carrier family 25 member 27 Solute carrier family 25, member 27, isoform CRA_a (cDNA FLJ57819, highly similar to Mitochondrial uncoupling protein 4) (cDNA, FLJ78839, highly similar to Mitochondrial uncoupling protein 4) |
Synonyms | UCP4 UNQ772/PRO1566 hCG_16892 |
Description | FUNCTION: Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated. . |
Accessions | ENST00000411689.6 [O95847-2] ENST00000604127.5 Q5VTS8 S4R3J2 ENST00000603486.5 S4R300 B4DHR4 ENST00000604616.1 O95847 ENST00000371347.10 [O95847-1] ENST00000604217.5 |