SLC25A24 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015866Biological processADP transport
GO_1990544Biological processmitochondrial ATP transmembrane transport
GO_0006839Biological processmitochondrial transport
GO_0034599Biological processcellular response to oxidative stress
GO_0051503Biological processadenine nucleotide transport
GO_0071277Biological processcellular response to calcium ion
GO_0015867Biological processATP transport
GO_0005743Cellular componentmitochondrial inner membrane
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0140987Molecular functionATP:phosphate antiporter activity
GO_0005509Molecular functioncalcium ion binding
GO_0140988Molecular functionADP:phosphate antiporter activity
GO_0000295Molecular functionadenine nucleotide transmembrane transporter activity
GO_0005347Molecular functionATP transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC25A24
Protein nameCalcium-binding mitochondrial carrier protein SCaMC-1 (Solute carrier family 25 member 24)
Mitochondrial adenyl nucleotide antiporter SLC25A24 (Mitochondrial ATP-Mg/Pi carrier protein 1) (Mitochondrial Ca(2+)-dependent solute carrier protein 1) (Short calcium-binding mitochondrial carrier protein 1) (SCaMC-1) (Solute carrier family 25 member 24)
SynonymsMCSC1
SCAMC1
APC1
DescriptionFUNCTION: Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways . In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides . May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates . .

AccessionsA0A3B3IU96
ENST00000640416.2 [Q6NUK1-1]
H3BMI3
ENST00000569674.1
ENST00000639032.1 [Q6NUK1-2]
ENST00000649955.1
ENST00000565488.6 [Q6NUK1-1]
Q6NUK1
ENST00000370041.4 [Q6NUK1-2]
ENST00000640018.1
ENST00000264128.13
ENST00000648874.1
ENST00000639606.1
J3KN42