SLC25A23 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0003014Biological processrenal system process
GO_0051503Biological processadenine nucleotide transport
GO_0015867Biological processATP transport
GO_0015866Biological processADP transport
GO_0051282Biological processregulation of sequestering of calcium ion
GO_0051561Biological processpositive regulation of mitochondrial calcium ion concentration
GO_0071277Biological processcellular response to calcium ion
GO_0002082Biological processregulation of oxidative phosphorylation
GO_1990544Biological processmitochondrial ATP transmembrane transport
GO_1900069Biological processregulation of cellular hyperosmotic salinity response
GO_0006851Biological processmitochondrial calcium ion transmembrane transport
GO_0036444Biological processcalcium import into the mitochondrion
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0140987Molecular functionATP:phosphate antiporter activity
GO_0005347Molecular functionATP transmembrane transporter activity
GO_0005509Molecular functioncalcium ion binding
GO_0140988Molecular functionADP:phosphate antiporter activity
GO_0005515Molecular functionprotein binding
GO_0000295Molecular functionadenine nucleotide transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC25A23
Protein nameMitochondrial adenyl nucleotide antiporter SLC25A23 (Mitochondrial ATP-Mg/Pi carrier protein 2) (Short calcium-binding mitochondrial carrier protein 3) (SCaMC-3) (Solute carrier family 25 member 23)
Solute carrier family 25 member 23
Mitochondrial ATP-Mg/Pi carrier protein
SynonymsMCSC2
APC2
SCAMC3
DescriptionFUNCTION: Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways . Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP . In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides . .

AccessionsM0R2F3
M0QZT4
ENST00000595810.5
M0QZP9
ENST00000601322.5
Q9BV35
ENST00000264088.8 [Q9BV35-3]
ENST00000593600.5
M0R2I4
M0QZJ5
Q4LBC5
M0R1W8
ENST00000600682.5
ENST00000598704.5
ENST00000597307.1
ENST00000334510.9 [Q9BV35-2]
Q4LBC4
ENST00000301454.9 [Q9BV35-1]
M0R1X8
ENST00000598908.5