SLC22A7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC22A7 at tissue level.

III. Associated gene sets

GO_0006811Biological processmonoatomic ion transport
GO_0006805Biological processxenobiotic metabolic process
GO_0015732Biological processprostaglandin transport
GO_0015742Biological processalpha-ketoglutarate transport
GO_0015711Biological processorganic anion transport
GO_0055085Biological processtransmembrane transport
GO_0016323Cellular componentbasolateral plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0009925Cellular componentbasal plasma membrane
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0015139Molecular functionalpha-ketoglutarate transmembrane transporter activity
GO_0015132Molecular functionprostaglandin transmembrane transporter activity
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0015347Molecular functionsodium-independent organic anion transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC22A7
Protein nameSolute carrier family 22 member 7
SLC22A7 protein (Solute carrier family 22 (Organic anion transporter), member 7, isoform CRA_d)
Solute carrier family 22 member 7 (Novel liver transporter) (NLT) (Organic anion transporter 2) (hOAT2)
SynonymsNLT
OAT2
hCG_19011
DescriptionFUNCTION: [Isoform 2]: Functions as a Na(+)-independent bidirectional multispecific transporter . Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively . Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides and nucleotides, with cGMP, 2'deoxyguanosine and GMP being the preferred substrates . Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways . Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood . Involved in renal secretion and possible reabsorption of creatinine . Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (Probable). Also transports alpha-ketoglutarate and urate . Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified . .; FUNCTION: [Isoform 1]: Non functional transporter. .; FUNCTION: [Isoform 3]: Involved in the uptake of prostaglandin F2-alpha (PGF2-alpha). .

AccessionsX6RDF7
ENST00000372585.10 [Q9Y694-1]
Q9Y694
Q5T051
ENST00000372574.7 [Q9Y694-3]
Q8WWC3
Q5T047
ENST00000436107.1
ENST00000372589.7 [Q9Y694-2]
ENST00000451757.5
ENST00000449231.5