SLC22A6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055085Biological processtransmembrane transport
GO_0014070Biological processresponse to organic cyclic compound
GO_0072237Biological processmetanephric proximal tubule development
GO_0097254Biological processrenal tubular secretion
GO_0042908Biological processxenobiotic transport
GO_0006820Biological processmonoatomic anion transport
GO_0015732Biological processprostaglandin transport
GO_0015742Biological processalpha-ketoglutarate transport
GO_0015711Biological processorganic anion transport
GO_0043252Biological processsodium-independent organic anion transport
GO_0015698Biological processinorganic anion transport
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0009925Cellular componentbasal plasma membrane
GO_0005901Cellular componentcaveola
GO_0016323Cellular componentbasolateral plasma membrane
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0031404Molecular functionchloride ion binding
GO_0015297Molecular functionantiporter activity
GO_0042802Molecular functionidentical protein binding
GO_0042910Molecular functionxenobiotic transmembrane transporter activity
GO_0015347Molecular functionsodium-independent organic anion transmembrane transporter activity
GO_0015139Molecular functionalpha-ketoglutarate transmembrane transporter activity
GO_0015132Molecular functionprostaglandin transmembrane transporter activity
GO_0005452Molecular functionsolute:inorganic anion antiporter activity
GO_0005515Molecular functionprotein binding
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC22A6
Protein nameSolute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1)
Solute carrier family 22 member 6
SynonymsOAT1
PAHT
DescriptionFUNCTION: Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate . Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine . Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins . Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion . Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP . Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain . May transport glutamate . Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body . Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate . Xenobiotics include the mycotoxin ochratoxin (OTA) . May also contribute to the transport of organic compounds in testes across the blood-testis-barrier . .

AccessionsENST00000540654.5
Q4U2R8
ENST00000458333.6 [Q4U2R8-3]
ENST00000377871.7 [Q4U2R8-1]
F5H0T7
ENST00000421062.2 [Q4U2R8-4]
ENST00000360421.9 [Q4U2R8-2]