SLC22A4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC22A4 at tissue level.

III. Associated gene sets

GO_0015697Biological processquaternary ammonium group transport
GO_0042908Biological processxenobiotic transport
GO_0089718Biological processamino acid import across plasma membrane
GO_1902603Biological processcarnitine transmembrane transport
GO_0009437Biological processcarnitine metabolic process
GO_0006814Biological processsodium ion transport
GO_0006641Biological processtriglyceride metabolic process
GO_1901374Biological processacetate ester transport
GO_0006836Biological processneurotransmitter transport
GO_0015879Biological processcarnitine transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0009925Cellular componentbasal plasma membrane
GO_0015171Molecular functionamino acid transmembrane transporter activity
GO_0015651Molecular functionquaternary ammonium group transmembrane transporter activity
GO_0015293Molecular functionsymporter activity
GO_0015226Molecular functioncarnitine transmembrane transporter activity
GO_0008513Molecular functionsecondary active organic cation transmembrane transporter activity
GO_0030165Molecular functionPDZ domain binding
GO_0015199Molecular functionamino-acid betaine transmembrane transporter activity
GO_0005277Molecular functionacetylcholine transmembrane transporter activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC22A4
Protein nameSolute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (ETTh) (Organic cation/carnitine transporter 1) (OCTN1)
Solute carrier family 22 member 4
SynonymsETT
OCTN1
UT2H
DescriptionFUNCTION: Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations . Functions as a Na(+)-dependent and pH-dependent high affinity microbial symporter of potent food-derived antioxidant ergothioeine . Transports one sodium ion with one ergothioeine molecule (By similarity). Involved in the absorption of ergothioneine from the luminal/apical side of the small intestine and renal tubular cells, and into non-parenchymal liver cells, thereby contributing to maintain steady-state ergothioneine level in the body . Also mediates the bidirectional transport of acetycholine, although the exact transport mechanism has not been fully identified yet . Most likely exports anti-inflammatory acetylcholine in non-neuronal tissues, thereby contributing to the non-neuronal cholinergic system . Displays a general physiological role linked to better survival by controlling inflammation and oxidative stress, which may be related to ergothioneine and acetycholine transports . May also function as a low-affinity Na(+)-dependent transporter of L-carnitine through the mitochondrial membrane, thereby maintaining intracellular carnitine homeostasis . May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier . .

AccessionsD9N2T6
ENST00000200652.4
Q9H015