SLC22A2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC22A2 at tissue level.

III. Associated gene sets

GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0015695Biological processorganic cation transport
GO_0015697Biological processquaternary ammonium group transport
GO_0015847Biological processputrescine transport
GO_0150104Biological processtransport across blood-brain barrier
GO_1990962Biological processxenobiotic transport across blood-brain barrier
GO_0010628Biological processpositive regulation of gene expression
GO_0090494Biological processdopamine uptake
GO_1903711Biological processspermidine transmembrane transport
GO_1903826Biological processL-arginine transmembrane transport
GO_1990748Biological processcellular detoxification
GO_0071934Biological processthiamine transmembrane transport
GO_0140115Biological processexport across plasma membrane
GO_0007589Biological processbody fluid secretion
GO_0048241Biological processepinephrine transport
GO_0015872Biological processdopamine transport
GO_0042908Biological processxenobiotic transport
GO_0089718Biological processamino acid import across plasma membrane
GO_0051620Biological processnorepinephrine uptake
GO_0015837Biological processamine transport
GO_0015732Biological processprostaglandin transport
GO_0006837Biological processserotonin transport
GO_0015870Biological processacetylcholine transport
GO_1902475Biological processL-alpha-amino acid transmembrane transport
GO_0006836Biological processneurotransmitter transport
GO_0097638Biological processL-arginine import across plasma membrane
GO_0015874Biological processnorepinephrine transport
GO_0051610Biological processserotonin uptake
GO_0006812Biological processmonoatomic cation transport
GO_0051608Biological processhistamine transport
GO_0072530Biological processpurine-containing compound transmembrane transport
GO_0015871Biological processcholine transport
GO_0051615Biological processhistamine uptake
GO_0015848Biological processspermidine transport
GO_0016324Cellular componentapical plasma membrane
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0009925Cellular componentbasal plasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0015214Molecular functionpyrimidine nucleoside transmembrane transporter activity
GO_0061459Molecular functionL-arginine transmembrane transporter activity
GO_0015179Molecular functionL-amino acid transmembrane transporter activity
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0015562Molecular functionefflux transmembrane transporter activity
GO_0015220Molecular functioncholine transmembrane transporter activity
GO_0015489Molecular functionputrescine transmembrane transporter activity
GO_0015101Molecular functionorganic cation transmembrane transporter activity
GO_0015651Molecular functionquaternary ammonium group transmembrane transporter activity
GO_0005326Molecular functionneurotransmitter transmembrane transporter activity
GO_0005275Molecular functionamine transmembrane transporter activity
GO_0008504Molecular functionmonoamine transmembrane transporter activity
GO_0015606Molecular functionspermidine transmembrane transporter activity
GO_0019534Molecular functiontoxin transmembrane transporter activity
GO_0042910Molecular functionxenobiotic transmembrane transporter activity
GO_0005277Molecular functionacetylcholine transmembrane transporter activity
GO_0015132Molecular functionprostaglandin transmembrane transporter activity
GO_0015234Molecular functionthiamine transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC22A2
Protein nameSolute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2)
Solute carrier family 22 member 2
SynonymsOCT2
DescriptionFUNCTION: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics . Functions as a Na(+)-independent, bidirectional uniporter . Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient . However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (By similarity). Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow . Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters . Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system . Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium . Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN) . Mediates the uptake and efflux of quaternary ammonium compound choline . Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamines putrescine and spermidine . Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) . Also involved in the uptake of xenobiotic 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) . May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). .; FUNCTION: [Isoform 2]: In contrast with isoform 1, not able to transport guanidine, creatinine, cimetidine and metformin. .

AccessionsENST00000366952.1
ENST00000366953.8 [O15244-1]
Q5T7Q5
O15244