SLC22A15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006811Biological processmonoatomic ion transport
GO_0015838Biological processamino-acid betaine transport
GO_0006865Biological processamino acid transport
GO_0008150Biological processbiological_process
GO_0055085Biological processtransmembrane transport
GO_0005575Cellular componentcellular_component
GO_0005886Cellular componentplasma membrane
GO_0015199Molecular functionamino-acid betaine transmembrane transporter activity
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameSLC22A15
Protein nameSolute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1)
Solute carrier family 22 member 15 isoform 7
Solute carrier family 22 member 15 isoform 5
Solute carrier family 22 member 15 isoform 4
Solute carrier family 22 member 15 isoform 2 (Solute carrier family 22 member 15 isoform 6)
Solute carrier family 22 member 15 isoform 1
SynonymsUNQ9429/PRO34686
FLIPT1
DescriptionFUNCTION: Organic zwitterion/cation transporter with apparent specificity for amino acids and their derivatives. Has low affinity for its substrates and may regulate their flux across the plasma membrane at high substrate concentrations . Bidirectionally transports carnitine and acetylcarnitine, possibly regulating their cytosolic abundance and further fatty acid catabolism via beta oxidation . Displays high transport activity toward zwitterionic substrates such as glycine betaine and diet-derived ergothioneine and carnosine. Can transport cations having an indole skeleton such as thiamine with lower efficiency. Does not transport agmatine . The transport mechanism, symport with sodium or facilitated diffusion allosterically regulated by sodium, remains to be elucidated (Probable). .

AccessionsENST00000369503.9 [Q8IZD6-1]
A0A0S2Z6C8
A0A0S2Z5J2
A0A0S2Z5M4
A0A0S2Z5P9
Q8IZD6
ENST00000369502.1 [Q8IZD6-2]
A0A0S2Z5R0