SLC22A14 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	3 studies	24% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC22A14 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	53.97	89 / 89	6%	0.12	57 / 901
bladder	95%	17.67	20 / 21	2%	0.03	8 / 504
brain	95%	62.24	2504 / 2642	0%	0.00	2 / 705
prostate	93%	21.80	229 / 245	0%	0	0 / 502
esophagus	88%	18.84	1274 / 1445	2%	0.03	3 / 183
muscle	88%	21.51	706 / 803	0%	0	0 / 0
spleen	85%	15.72	206 / 241	0%	0	0 / 0
adipose	84%	13.32	1015 / 1204	0%	0	0 / 0
lung	83%	12.57	479 / 578	1%	0.03	11 / 1155
intestine	82%	12.03	793 / 966	0%	0.01	2 / 527
breast	80%	12.97	367 / 459	0%	0.00	4 / 1118
blood vessel	80%	11.18	1070 / 1335	0%	0	0 / 0
thymus	79%	10.82	513 / 653	0%	0	0 / 605
peripheral blood	78%	26.81	722 / 929	0%	0	0 / 0
uterus	75%	9.88	127 / 170	1%	0.01	4 / 459
heart	69%	10.73	593 / 861	0%	0	0 / 0
liver	68%	9.03	153 / 226	0%	0	0 / 406
skin	64%	8.72	1157 / 1809	0%	0.03	2 / 472
stomach	54%	6.18	194 / 359	1%	0.01	2 / 286
adrenal gland	54%	6.88	140 / 258	0%	0.00	1 / 230
ovary	49%	5.39	89 / 180	1%	0.02	4 / 430
pancreas	39%	3.90	127 / 328	1%	0.01	1 / 178
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0030317	Biological process	flagellated sperm motility
GO_0048240	Biological process	sperm capacitation
GO_0032218	Biological process	riboflavin transport
GO_0055085	Biological process	transmembrane transport
GO_0097228	Cellular component	sperm principal piece
GO_0005886	Cellular component	plasma membrane
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0032217	Molecular function	riboflavin transmembrane transporter activity
GO_0005515	Molecular function	protein binding

Gene name	SLC22A14
Protein name	Solute carrier family 22 member 14 Solute carrier family 22 member 14 (Organic cation transporter-like 4) (ORCTL-4)
Synonyms	OCTL2 ORCTL4
Description	FUNCTION: Riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa midpiece, which is required for male fertility (By similarity). SLC22A14-mediated riboflavin transport is essential for spermatozoa energy generation and motility: riboflavin is the precursor of FMN and FAD, which are coenzymes of many enzymes in the TCA cycle (the citric acid cycle) in mitochondria (By similarity). Required for sperm motility and normal sperm flagellar structure (By similarity). .
Accessions	ENST00000448498.6 ENST00000273173.4 F5H7H1 Q9Y267 ENST00000466887.5

SLC22A14 report