SLC22A12 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLC22A12 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC22A12 at tissue level.

III. Associated gene sets

GO_0046415Biological processurate metabolic process
GO_0006811Biological processmonoatomic ion transport
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0097744Biological processrenal urate salt excretion
GO_0015747Biological processurate transport
GO_0032869Biological processcellular response to insulin stimulus
GO_0015711Biological processorganic anion transport
GO_0055085Biological processtransmembrane transport
GO_0019725Biological processcellular homeostasis
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0030165Molecular functionPDZ domain binding
GO_0015143Molecular functionurate transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC22A12
Protein nameSolute carrier family 22 member 12 (Organic anion transporter 4-like protein) (Renal-specific transporter) (RST) (Urate anion exchanger 1) (URAT1) (Urate:anion antiporter SLC22A12)
URAT1 transporter protein
SLC22A12 protein
SynonymsOATL4
URAT1
UNQ6453/PRO34004
DescriptionFUNCTION: Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions . Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid . Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) . Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate . Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption . Orotate transport is Cl(-)-dependent . .

AccessionsENST00000377574.6 [Q96S37-1]
ENST00000377567.6 [Q96S37-2]
ENST00000336464.7 [Q96S37-4]
ENST00000377572.5 [Q96S37-2]
Q96S37
ENST00000473690.5 [Q96S37-3]
Q05CF4
Q19PG1