SLC22A1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC22A1 at tissue level.

III. Associated gene sets

GO_0015844Biological processmonoamine transport
GO_1902616Biological processacyl carnitine transmembrane transport
GO_0015695Biological processorganic cation transport
GO_0006805Biological processxenobiotic metabolic process
GO_0015697Biological processquaternary ammonium group transport
GO_0015888Biological processthiamine transport
GO_0015847Biological processputrescine transport
GO_0150104Biological processtransport across blood-brain barrier
GO_1902270Biological process(R)-carnitine transmembrane transport
GO_1990962Biological processxenobiotic transport across blood-brain barrier
GO_0090494Biological processdopamine uptake
GO_1903711Biological processspermidine transmembrane transport
GO_1990748Biological processcellular detoxification
GO_0072237Biological processmetanephric proximal tubule development
GO_0071934Biological processthiamine transmembrane transport
GO_0048241Biological processepinephrine transport
GO_0015872Biological processdopamine transport
GO_0042908Biological processxenobiotic transport
GO_0051620Biological processnorepinephrine uptake
GO_0015732Biological processprostaglandin transport
GO_0006837Biological processserotonin transport
GO_0098655Biological processmonoatomic cation transmembrane transport
GO_0010248Biological processestablishment or maintenance of transmembrane electrochemical gradient
GO_0015870Biological processacetylcholine transport
GO_0006836Biological processneurotransmitter transport
GO_0015874Biological processnorepinephrine transport
GO_0051610Biological processserotonin uptake
GO_0072530Biological processpurine-containing compound transmembrane transport
GO_0015848Biological processspermidine transport
GO_0016324Cellular componentapical plasma membrane
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0009925Cellular componentbasal plasma membrane
GO_0016328Cellular componentlateral plasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0015214Molecular functionpyrimidine nucleoside transmembrane transporter activity
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0015489Molecular functionputrescine transmembrane transporter activity
GO_0015101Molecular functionorganic cation transmembrane transporter activity
GO_0015651Molecular functionquaternary ammonium group transmembrane transporter activity
GO_0005326Molecular functionneurotransmitter transmembrane transporter activity
GO_0008513Molecular functionsecondary active organic cation transmembrane transporter activity
GO_0042802Molecular functionidentical protein binding
GO_0005334Molecular functionnorepinephrine:sodium symporter activity
GO_0008504Molecular functionmonoamine transmembrane transporter activity
GO_0015606Molecular functionspermidine transmembrane transporter activity
GO_0019534Molecular functiontoxin transmembrane transporter activity
GO_0042910Molecular functionxenobiotic transmembrane transporter activity
GO_0005277Molecular functionacetylcholine transmembrane transporter activity
GO_0005330Molecular functiondopamine:sodium symporter activity
GO_1901235Molecular function(R)-carnitine transmembrane transporter activity
GO_0015132Molecular functionprostaglandin transmembrane transporter activity
GO_0015234Molecular functionthiamine transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC22A1
Protein nameSolute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1)
Solute carrier family 22 member 1
SynonymsOCT1
DescriptionFUNCTION: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics . Functions as a pH- and Na(+)-independent, bidirectional transporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (By similarity). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (By similarity). Primarily expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (By similarity). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal elimination of organic cations from the systemic circulation . Transports endogenous monoamines such as N-1-methylnicotinamide (NMN), guanidine, histamine, neurotransmitters dopamine, serotonin and adrenaline . Also transports natural polyamines such as spermidine, agmatine and putrescine at low affinity, but relatively high turnover . Involved in the hepatic uptake of vitamin B1/thiamine, hence regulating hepatic lipid and energy metabolism . Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium . Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with lower efficency . Also capable of transporting non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) . May contribute to the transport of cationic compounds in testes across the blood-testis-barrier (Probable). Also involved in the uptake of xenobiotics tributylmethylammonium (TBuMA), quinidine, N-methyl-quinine (NMQ), N-methyl-quinidine (NMQD) N-(4,4-azo-n-pentyl)-quinuclidine (APQ), azidoprocainamide methoiodide (AMP), N-(4,4-azo-n-pentyl)-21-deoxyajmalinium (APDA) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) . .; FUNCTION: [Isoform 1]: Mediates the uptake of 1-methyl-4-phenylpyridinium (MPP(+)). .; FUNCTION: [Isoform 2]: Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+)). .; FUNCTION: [Isoform 3]: Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+)). .; FUNCTION: [Isoform 4]: Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+)). .

AccessionsENST00000366963.9 [O15245-1]
ENST00000457470.6 [O15245-3]
ENST00000539263.5
ENST00000460902.2 [O15245-4]
F5GY86
ENST00000324965.8 [O15245-2]
ENST00000540443.1
F5H5P3
O15245