I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 20% ± 3% | |
| GABAergic neuron | 3 studies | 18% ± 2% | |
| interneuron | 3 studies | 20% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 20% ± 3% | |
| GABAergic neuron | 3 studies | 18% ± 2% | |
| interneuron | 3 studies | 20% ± 1% |
Insufficient scRNA-seq data for expression of SLC1A6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 90% | 1977.22 | 2372 / 2642 | 67% | 3.36 | 475 / 705 |
| skin | 70% | 563.78 | 1269 / 1809 | 4% | 0.19 | 20 / 472 |
| bladder | 0% | 0 | 0 / 21 | 30% | 10.18 | 149 / 504 |
| uterus | 1% | 5.23 | 2 / 170 | 19% | 5.54 | 88 / 459 |
| lung | 0% | 0 | 0 / 578 | 14% | 1.43 | 166 / 1155 |
| pancreas | 5% | 12.81 | 17 / 328 | 5% | 1.10 | 9 / 178 |
| esophagus | 0% | 0.27 | 1 / 1445 | 8% | 0.33 | 15 / 183 |
| kidney | 0% | 0 | 0 / 89 | 7% | 1.12 | 66 / 901 |
| adrenal gland | 0% | 4.14 | 1 / 258 | 7% | 1.39 | 15 / 230 |
| breast | 0% | 0 | 0 / 459 | 7% | 0.63 | 77 / 1118 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.10 | 2 / 45 |
| ovary | 1% | 1.58 | 1 / 180 | 2% | 0.19 | 9 / 430 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| prostate | 1% | 2.27 | 2 / 245 | 0% | 0.00 | 1 / 502 |
| intestine | 0% | 0.27 | 1 / 966 | 1% | 0.02 | 4 / 527 |
| stomach | 0% | 0 | 0 / 359 | 1% | 0.01 | 2 / 286 |
| liver | 0% | 0 | 0 / 226 | 0% | 0.01 | 2 / 406 |
| adipose | 0% | 1.87 | 5 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 0% | 0.24 | 1 / 653 | 0% | 0 | 0 / 605 |
| blood vessel | 0% | 0.83 | 2 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.19 | 1 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042391 | Biological process | regulation of membrane potential |
| GO_0015813 | Biological process | L-glutamate transmembrane transport |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0015810 | Biological process | aspartate transmembrane transport |
| GO_0098712 | Biological process | L-glutamate import across plasma membrane |
| GO_0051649 | Biological process | establishment of localization in cell |
| GO_0015804 | Biological process | neutral amino acid transport |
| GO_0001504 | Biological process | neurotransmitter uptake |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0006836 | Biological process | neurotransmitter transport |
| GO_0140009 | Biological process | L-aspartate import across plasma membrane |
| GO_0098796 | Cellular component | membrane protein complex |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0045111 | Cellular component | intermediate filament cytoskeleton |
| GO_0015501 | Molecular function | glutamate:sodium symporter activity |
| GO_0015183 | Molecular function | L-aspartate transmembrane transporter activity |
| GO_0015175 | Molecular function | neutral L-amino acid transmembrane transporter activity |
| GO_0005313 | Molecular function | L-glutamate transmembrane transporter activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005314 | Molecular function | high-affinity L-glutamate transmembrane transporter activity |
| Gene name | SLC1A6 |
| Protein name | Solute carrier family 1 member 6 Excitatory amino acid transporter 4 Amino acid transporter Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6) |
| Synonyms | EAAT4 |
| Description | FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate . Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport . Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). . |
| Accessions | P48664 ENST00000595863.1 ENST00000594383.2 [P48664-1] M0R063 ENST00000598504.5 [P48664-2] ENST00000599636.1 M0R2V7 ENST00000221742.7 [P48664-1] ENST00000544886.6 [P48664-2] M0R106 ENST00000430939.6 ENST00000597262.1 M0R0B5 M0QY32 E7EV13 ENST00000594383 M0R1V3 ENST00000601761.1 ENST00000600144.5 |
