SLC19A1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC19A1 at tissue level.

III. Associated gene sets

GO_0006855Biological processxenobiotic transmembrane transport
GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0141111Biological processpositive regulation of cGAS/STING signaling pathway
GO_0007565Biological processfemale pregnancy
GO_0051958Biological processmethotrexate transport
GO_0140361Biological processcyclic-GMP-AMP transmembrane import across plasma membrane
GO_1904447Biological processfolate import across plasma membrane
GO_0046655Biological processfolic acid metabolic process
GO_0098838Biological processfolate transmembrane transport
GO_0015711Biological processorganic anion transport
GO_0015884Biological processfolic acid transport
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0015350Molecular functionmethotrexate transmembrane transporter activity
GO_0042910Molecular functionxenobiotic transmembrane transporter activity
GO_0061507Molecular function2',3'-cyclic GMP-AMP binding
GO_0008517Molecular functionfolic acid transmembrane transporter activity
GO_0005542Molecular functionfolic acid binding
GO_0140360Molecular functioncyclic-GMP-AMP transmembrane transporter activity
GO_0008518Molecular functionfolate:monoatomic anion antiporter activity

IV. Literature review

[source]
Gene nameSLC19A1
Protein nameSLC19A1 protein
Solute carrier family 19 member 1
Reduced folate transporter (Solute carrier family 19 member 1)
Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)
SynonymsFLOT1
RFC1
DescriptionFUNCTION: Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions . Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates . Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate . Also able to mediate the import of antifolate drug methotrexate . Also acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses . 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity . .

FUNCTION: Transporter that mediates the import of reduced folates. .

AccessionsENST00000380010.8 [P41440-3]
ENST00000528477.1
H3BTQ3
A2VCN1
ENST00000427839.5
P41440
ENST00000485649.3 [P41440-2]
C9J8K6
C9JKP4
ENST00000443742.1
ENST00000311124.9 [P41440-1]
E9PIL5
ENST00000650808.1 [P41440-3]
H0Y4T2
ENST00000567670.5
ENST00000417954.5