SLC17A8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLC17A8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC17A8 at tissue level.

III. Associated gene sets

GO_0055062Biological processphosphate ion homeostasis
GO_0007605Biological processsensory perception of sound
GO_0051631Biological processregulation of acetylcholine uptake
GO_0015813Biological processL-glutamate transmembrane transport
GO_0006811Biological processmonoatomic ion transport
GO_0044341Biological processsodium-dependent phosphate transport
GO_0006820Biological processmonoatomic anion transport
GO_1902476Biological processchloride transmembrane transport
GO_0090102Biological processcochlea development
GO_0051938Biological processL-glutamate import
GO_0098700Biological processneurotransmitter loading into synaptic vesicle
GO_0050803Biological processregulation of synapse structure or activity
GO_0035725Biological processsodium ion transmembrane transport
GO_0003407Biological processneural retina development
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0051951Biological processpositive regulation of glutamate uptake involved in transmission of nerve impulse
GO_0097441Cellular componentbasal dendrite
GO_0005886Cellular componentplasma membrane
GO_0043204Cellular componentperikaryon
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0043679Cellular componentaxon terminus
GO_0034707Cellular componentchloride channel complex
GO_0005771Cellular componentmultivesicular body
GO_0097440Cellular componentapical dendrite
GO_0060076Cellular componentexcitatory synapse
GO_0097451Cellular componentglial limiting end-foot
GO_1990030Cellular componentpericellular basket
GO_0005436Molecular functionsodium:phosphate symporter activity
GO_0005326Molecular functionneurotransmitter transmembrane transporter activity
GO_0140788Molecular functionL-glutamate uniporter activity
GO_0005313Molecular functionL-glutamate transmembrane transporter activity
GO_0005254Molecular functionchloride channel activity

IV. Literature review

[source]
Gene nameSLC17A8
Protein nameVesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8)
SynonymsVGLUT3
DescriptionFUNCTION: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate . At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells . The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane . In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (Probable). The symporter activity is electrogenic . Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake (By similarity). .

AccessionsENST00000392989.3 [Q8NDX2-2]
Q8NDX2
ENST00000323346.10 [Q8NDX2-1]