SLC17A7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055062Biological processphosphate ion homeostasis
GO_0006813Biological processpotassium ion transport
GO_0006821Biological processchloride transport
GO_1900242Biological processregulation of synaptic vesicle endocytosis
GO_0015813Biological processL-glutamate transmembrane transport
GO_0006811Biological processmonoatomic ion transport
GO_0003407Biological processneural retina development
GO_0071805Biological processpotassium ion transmembrane transport
GO_0044341Biological processsodium-dependent phosphate transport
GO_0006820Biological processmonoatomic anion transport
GO_1902476Biological processchloride transmembrane transport
GO_0006836Biological processneurotransmitter transport
GO_0006817Biological processphosphate ion transport
GO_0098700Biological processneurotransmitter loading into synaptic vesicle
GO_0050803Biological processregulation of synapse structure or activity
GO_0035725Biological processsodium ion transmembrane transport
GO_1902600Biological processproton transmembrane transport
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0060203Cellular componentclathrin-sculpted glutamate transport vesicle membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0043005Cellular componentneuron projection
GO_0048786Cellular componentpresynaptic active zone
GO_0034707Cellular componentchloride channel complex
GO_0060076Cellular componentexcitatory synapse
GO_0005436Molecular functionsodium:phosphate symporter activity
GO_0005326Molecular functionneurotransmitter transmembrane transporter activity
GO_0015386Molecular functionpotassium:proton antiporter activity
GO_0140788Molecular functionL-glutamate uniporter activity
GO_0140787Molecular functionphosphate ion uniporter activity
GO_0005313Molecular functionL-glutamate transmembrane transporter activity
GO_0005254Molecular functionchloride channel activity

IV. Literature review

[source]
Gene nameSLC17A7
Protein nameVesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7)
Alternative protein SLC17A7
Vesicular glutamate transporter 1 (Solute carrier family 17 member 7)
SynonymsVGLUT1
BNPI
DescriptionFUNCTION: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate . At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (By similarity). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular K(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation . The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity). .

AccessionsENST00000221485.8 [Q9P2U7-1]
ENST00000600601.5 [Q9P2U7-2]
L8EA60
M0R1S5
Q9P2U7
ENST00000596689.1