SLC17A5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	7 studies	21% ± 5%	Explore
glutamatergic neuron	6 studies	39% ± 22%	Explore
retinal cone cell	6 studies	21% ± 3%	Explore
endothelial cell	5 studies	21% ± 3%	Explore
retinal rod cell	5 studies	26% ± 5%	Explore
goblet cell	5 studies	31% ± 12%	Explore
retinal ganglion cell	4 studies	26% ± 8%	Explore
myeloid cell	4 studies	20% ± 8%	Explore
epithelial cell	4 studies	32% ± 4%	Explore
GABAergic neuron	4 studies	43% ± 16%	Explore
astrocyte	4 studies	25% ± 7%	Explore
microglial cell	3 studies	20% ± 4%	Explore
alveolar macrophage	3 studies	24% ± 8%	Explore
interneuron	3 studies	40% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	4 studies	40% ± 14%	Explore
eye	3 studies	21% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	1267.71	244 / 245	99%	75.52	499 / 502
stomach	100%	1146.85	359 / 359	99%	31.98	283 / 286
breast	100%	1724.67	459 / 459	99%	38.80	1103 / 1118
pancreas	99%	867.52	325 / 328	99%	35.61	177 / 178
intestine	100%	1733.66	966 / 966	98%	36.06	519 / 527
lung	100%	1932.04	578 / 578	98%	28.51	1136 / 1155
kidney	100%	1765.47	89 / 89	97%	42.18	874 / 901
liver	100%	1225.92	226 / 226	96%	34.52	390 / 406
brain	98%	920.46	2579 / 2642	98%	22.74	694 / 705
bladder	100%	1190.24	21 / 21	95%	28.50	479 / 504
thymus	100%	4841.00	653 / 653	94%	151.50	568 / 605
adrenal gland	98%	1207.95	253 / 258	94%	51.30	217 / 230
skin	100%	1824.99	1807 / 1809	92%	31.54	436 / 472
esophagus	100%	1156.61	1445 / 1445	89%	22.53	163 / 183
ovary	96%	614.23	173 / 180	91%	19.84	392 / 430
uterus	100%	1167.04	170 / 170	84%	18.24	384 / 459
adipose	100%	1751.53	1204 / 1204	0%	0	0 / 0
spleen	100%	1005.93	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	55.29	1 / 1
blood vessel	100%	1915.61	1334 / 1335	0%	0	0 / 0
heart	95%	819.17	822 / 861	0%	0	0 / 0
muscle	91%	534.50	731 / 803	0%	0	0 / 0
peripheral blood	83%	641.94	773 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	80%	12.13	36 / 45
lymph node	0%	0	0 / 0	72%	8.80	21 / 29
eye	0%	0	0 / 0	55%	11.83	44 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042874	Biological process	D-glucuronate transmembrane transport
GO_0015739	Biological process	sialic acid transport
GO_0034219	Biological process	carbohydrate transmembrane transport
GO_0009617	Biological process	response to bacterium
GO_0006811	Biological process	monoatomic ion transport
GO_0006820	Biological process	monoatomic anion transport
GO_0006865	Biological process	amino acid transport
GO_1902600	Biological process	proton transmembrane transport
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005764	Cellular component	lysosome
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0005829	Cellular component	cytosol
GO_0005765	Cellular component	lysosomal membrane
GO_0016323	Cellular component	basolateral plasma membrane
GO_0015136	Molecular function	sialic acid transmembrane transporter activity
GO_0015538	Molecular function	sialic acid:proton symporter activity
GO_0042880	Molecular function	D-glucuronate transmembrane transporter activity
GO_0005351	Molecular function	carbohydrate:proton symporter activity

IV. Literature review

[source]

Gene name	SLC17A5
Protein name	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)
Synonyms
Description	FUNCTION: Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport . Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (By similarity). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva . Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release (By similarity). .; FUNCTION: Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties. .
Accessions	Q9NRA2 ENST00000355773.6 [Q9NRA2-1]

SLC17A5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review