SLC13A5 | OmnibusX

Name	Number of supported studies	Average coverage
liver	3 studies	42% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	33075.69	226 / 226	87%	55.87	355 / 406
brain	94%	495.91	2473 / 2642	30%	1.16	210 / 705
ovary	70%	77.32	126 / 180	41%	1.53	177 / 430
spleen	92%	577.73	221 / 241	0%	0	0 / 0
adrenal gland	73%	353.76	188 / 258	7%	0.86	16 / 230
esophagus	29%	52.11	419 / 1445	21%	1.86	38 / 183
pancreas	0%	0.25	1 / 328	48%	4.41	85 / 178
breast	31%	38.32	144 / 459	2%	0.10	23 / 1118
uterus	10%	12.27	17 / 170	19%	0.76	87 / 459
lung	1%	0.59	5 / 578	17%	1.09	192 / 1155
adipose	17%	19.75	203 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	16%	0.89	7 / 45
stomach	1%	0.30	2 / 359	7%	0.59	20 / 286
kidney	6%	16.31	5 / 89	1%	0.04	8 / 901
intestine	1%	0.94	10 / 966	5%	0.56	28 / 527
bladder	0%	0	0 / 21	6%	0.24	30 / 504
skin	1%	1.45	21 / 1809	2%	0.27	11 / 472
thymus	2%	1.47	11 / 653	1%	0.08	5 / 605
eye	0%	0	0 / 0	1%	0.03	1 / 80
peripheral blood	1%	2.70	11 / 929	0%	0	0 / 0
blood vessel	1%	1.02	12 / 1335	0%	0	0 / 0
prostate	1%	0.53	2 / 245	0%	0	0 / 502
heart	1%	1.07	7 / 861	0%	0	0 / 0
muscle	0%	0.13	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0071422	Biological process	succinate transmembrane transport
GO_0015744	Biological process	succinate transport
GO_0015746	Biological process	citrate transport
GO_0015742	Biological process	alpha-ketoglutarate transport
GO_0015741	Biological process	fumarate transport
GO_0035674	Biological process	tricarboxylic acid transmembrane transport
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0055085	Biological process	transmembrane transport
GO_0015729	Biological process	oxaloacetate transport
GO_0071285	Biological process	cellular response to lithium ion
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0015141	Molecular function	succinate transmembrane transporter activity
GO_0005343	Molecular function	organic acid:sodium symporter activity
GO_0015137	Molecular function	citrate transmembrane transporter activity
GO_0005515	Molecular function	protein binding
GO_0017153	Molecular function	sodium:dicarboxylate symporter activity

Gene name	SLC13A5
Protein name	Solute carrier family 13 member 5 Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)
Synonyms	NACT
Description	FUNCTION: High-affinity sodium/citrate cotransporter that mediates the entry of citrate into cells, which is a critical participant of biochemical pathways . May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis . Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form . Can recognize succinate as a substrate, but its affinity for succinate is several fold lower than for citrate . The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic . Involved in the regulation of citrate levels in the brain (By similarity). .
Accessions	I3L4X6 ENST00000381074.8 [Q86YT5-4] ENST00000575230.1 ENST00000572352.5 Q86YT5 ENST00000572094.1 ENST00000293800.10 [Q86YT5-3] I3L424 ENST00000570687.1 ENST00000573648.5 [Q86YT5-2] I3L2Y7 I3L4S9 ENST00000433363.7 [Q86YT5-1]

SLC13A5 report