SLC13A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034775Biological processglutathione transmembrane transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0071422Biological processsuccinate transmembrane transport
GO_0015746Biological processcitrate transport
GO_0015742Biological processalpha-ketoglutarate transport
GO_0006835Biological processdicarboxylic acid transport
GO_0035725Biological processsodium ion transmembrane transport
GO_0006869Biological processlipid transport
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0016323Cellular componentbasolateral plasma membrane
GO_0015137Molecular functioncitrate transmembrane transporter activity
GO_0005310Molecular functiondicarboxylic acid transmembrane transporter activity
GO_0017153Molecular functionsodium:dicarboxylate symporter activity
GO_0015362Molecular functionhigh-affinity sodium:dicarboxylate symporter activity
GO_0034634Molecular functionglutathione transmembrane transporter activity
GO_0015139Molecular functionalpha-ketoglutarate transmembrane transporter activity
GO_0015141Molecular functionsuccinate transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC13A3
Protein nameHCG2018530, isoform CRA_c (Solute carrier family 13 member 3)
Solute carrier family 13 member 3
Na(+)/dicarboxylate cotransporter 3 (NaDC-3) (hNaDC3) (Na(+)-coupled carboxylate transporter 3) (NaC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) (Solute carrier family 13 member 3) (SLC13A3)
SynonymsNADC3
SDCT2
hCG_2018530
DescriptionFUNCTION: High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate . Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic . Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood . .

AccessionsA0A0A0MRQ6
ENST00000417157.2
ENST00000468915.5
ENST00000290317.9 [Q8WWT9-6]
ENST00000420568.5
X6RDV4
Q8WWT9
ENST00000372121.5
C9J7L4
ENST00000279027.9 [Q8WWT9-1]
ENST00000413164.6 [Q8WWT9-5]
H7C0C8
ENST00000472148.5 [Q8WWT9-3]
C9J4A3
ENST00000495082.5 [Q8WWT9-6]
ENST00000450298.5