SLC10A1 | OmnibusX

Name	Number of supported studies	Average coverage
hepatocyte	3 studies	20% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC10A1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	7029.23	226 / 226	86%	169.93	348 / 406
ureter	0%	0	0 / 0	100%	6.47	1 / 1
spleen	98%	18.04	235 / 241	0%	0	0 / 0
ovary	88%	7.19	158 / 180	2%	0.22	8 / 430
thymus	90%	7.32	585 / 653	0%	0	0 / 605
intestine	86%	8.09	833 / 966	3%	0.31	15 / 527
stomach	85%	6.29	306 / 359	3%	0.10	10 / 286
lung	86%	6.87	498 / 578	3%	0.13	29 / 1155
adrenal gland	88%	5.57	227 / 258	0%	0	0 / 230
esophagus	85%	6.39	1230 / 1445	2%	0.05	4 / 183
peripheral blood	85%	21.50	789 / 929	0%	0	0 / 0
pancreas	82%	5.52	270 / 328	2%	0.18	3 / 178
uterus	81%	6.30	138 / 170	1%	0.03	5 / 459
prostate	81%	5.00	198 / 245	1%	0.04	3 / 502
breast	79%	5.11	363 / 459	2%	0.08	23 / 1118
bladder	71%	4.48	15 / 21	9%	1.88	43 / 504
adipose	78%	6.18	943 / 1204	0%	0	0 / 0
brain	77%	6.95	2043 / 2642	0%	0.03	1 / 705
skin	75%	4.57	1349 / 1809	0%	0.01	1 / 472
kidney	73%	4.01	65 / 89	2%	0.19	15 / 901
blood vessel	67%	3.58	893 / 1335	0%	0	0 / 0
heart	66%	3.67	570 / 861	0%	0	0 / 0
muscle	56%	2.26	448 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45

GO_0015721	Biological process	bile acid and bile salt transport
GO_0038183	Biological process	bile acid signaling pathway
GO_0031667	Biological process	response to nutrient levels
GO_0120188	Biological process	regulation of bile acid secretion
GO_0046718	Biological process	symbiont entry into host cell
GO_0014070	Biological process	response to organic cyclic compound
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0006814	Biological process	sodium ion transport
GO_0043627	Biological process	response to estrogen
GO_0045471	Biological process	response to ethanol
GO_0055085	Biological process	transmembrane transport
GO_0005886	Cellular component	plasma membrane
GO_0016323	Cellular component	basolateral plasma membrane
GO_0008508	Molecular function	bile acid:sodium symporter activity
GO_0001618	Molecular function	virus receptor activity
GO_0005515	Molecular function	protein binding

Gene name	SLC10A1
Protein name	Na+-taurocholate cotransporting polypeptide Hepatic sodium/bile acid cotransporter (Cell growth-inhibiting gene 29 protein) (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (NTCP) (Solute carrier family 10 member 1) (SLC10A1)
Synonyms	NTCP GIG29
Description	FUNCTION: As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins . It is strictly dependent on the extracellular presence of sodium . It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate . Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation . .; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis B virus. .
Accessions	ENST00000216540.5 K7PFC0 Q14973

SLC10A1 report