SKA3 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of SKA3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	92%	511.36	1656 / 1809	91%	14.53	430 / 472
intestine	56%	90.42	539 / 966	96%	28.64	508 / 527
stomach	48%	63.54	173 / 359	99%	26.61	282 / 286
esophagus	44%	139.62	638 / 1445	99%	23.18	181 / 183
lung	56%	50.27	323 / 578	82%	12.26	950 / 1155
bladder	29%	11.86	6 / 21	94%	19.75	475 / 504
breast	34%	15.88	156 / 459	85%	12.63	949 / 1118
uterus	15%	8.24	26 / 170	98%	21.11	451 / 459
ovary	14%	10.96	25 / 180	97%	15.10	417 / 430
tonsil	0%	0	0 / 0	100%	23.47	45 / 45
ureter	0%	0	0 / 0	100%	8.82	1 / 1
spleen	98%	148.04	235 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	20.85	28 / 29
brain	48%	21.18	1271 / 2642	44%	6.06	307 / 705
pancreas	12%	5.03	40 / 328	65%	5.44	116 / 178
adrenal gland	54%	29.62	139 / 258	11%	1.14	26 / 230
peripheral blood	61%	419.88	563 / 929	0%	0	0 / 0
liver	16%	18.41	36 / 226	40%	3.69	163 / 406
kidney	38%	27.56	34 / 89	11%	0.79	96 / 901
prostate	31%	13.57	75 / 245	16%	1.28	82 / 502
thymus	16%	7.24	106 / 653	14%	4.64	87 / 605
adipose	29%	16.66	350 / 1204	0%	0	0 / 0
blood vessel	16%	7.15	215 / 1335	0%	0	0 / 0
heart	12%	5.98	102 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	11%	0.61	9 / 80
muscle	8%	2.05	61 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0031110	Biological process	regulation of microtubule polymerization or depolymerization
GO_0051315	Biological process	attachment of mitotic spindle microtubules to kinetochore
GO_0051301	Biological process	cell division
GO_0000278	Biological process	mitotic cell cycle
GO_0007059	Biological process	chromosome segregation
GO_0000070	Biological process	mitotic sister chromatid segregation
GO_0005813	Cellular component	centrosome
GO_0000776	Cellular component	kinetochore
GO_0000940	Cellular component	outer kinetochore
GO_0005876	Cellular component	spindle microtubule
GO_0005829	Cellular component	cytosol
GO_0072686	Cellular component	mitotic spindle
GO_0005515	Molecular function	protein binding
GO_0008017	Molecular function	microtubule binding

Gene name	SKA3
Protein name	Spindle and kinetochore associated complex subunit 3 Spindle and kinetochore-associated protein 3
Synonyms	RAMA1 C13orf3
Description	FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation . The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies . The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner . In the complex, it mediates the microtubule-stimulated oligomerization . Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules . .
Accessions	ENST00000400018.7 [Q8IX90-3] Q8IX90 ENST00000462482.1 ENST00000298260.8 [Q8IX90-2] F5H8H7 F5GWG1 ENST00000465471.5 ENST00000314759.6 [Q8IX90-1]

SKA3 report