SKA1 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of SKA1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	89%	325.96	1602 / 1809	93%	12.38	440 / 472
lung	67%	52.12	390 / 578	83%	11.53	954 / 1155
intestine	56%	75.72	539 / 966	93%	12.11	490 / 527
stomach	52%	59.79	186 / 359	95%	12.34	271 / 286
esophagus	45%	112.78	652 / 1445	98%	14.31	180 / 183
bladder	43%	16.00	9 / 21	94%	15.51	474 / 504
uterus	19%	7.63	32 / 170	98%	21.45	450 / 459
breast	33%	13.31	150 / 459	84%	10.63	938 / 1118
ovary	12%	7.98	22 / 180	90%	9.57	386 / 430
adrenal gland	82%	63.99	211 / 258	20%	3.32	46 / 230
lymph node	0%	0	0 / 0	100%	29.25	29 / 29
tonsil	0%	0	0 / 0	100%	26.13	45 / 45
ureter	0%	0	0 / 0	100%	7.86	1 / 1
spleen	98%	172.75	236 / 241	0%	0	0 / 0
pancreas	53%	19.91	173 / 328	44%	3.62	79 / 178
peripheral blood	78%	466.76	722 / 929	0%	0	0 / 0
liver	19%	18.10	43 / 226	57%	5.52	233 / 406
brain	27%	18.13	703 / 2642	39%	4.05	273 / 705
prostate	29%	11.16	70 / 245	15%	0.80	76 / 502
thymus	19%	7.25	125 / 653	15%	2.37	90 / 605
adipose	33%	16.12	402 / 1204	0%	0	0 / 0
kidney	24%	14.94	21 / 89	9%	0.65	85 / 901
blood vessel	16%	6.39	219 / 1335	0%	0	0 / 0
heart	13%	5.86	116 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	6%	0.24	5 / 80
muscle	1%	0.35	11 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0031110	Biological process	regulation of microtubule polymerization or depolymerization
GO_0051315	Biological process	attachment of mitotic spindle microtubules to kinetochore
GO_0051301	Biological process	cell division
GO_0000278	Biological process	mitotic cell cycle
GO_0007059	Biological process	chromosome segregation
GO_0000070	Biological process	mitotic sister chromatid segregation
GO_0000776	Cellular component	kinetochore
GO_0000940	Cellular component	outer kinetochore
GO_0005876	Cellular component	spindle microtubule
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0034451	Cellular component	centriolar satellite
GO_0072686	Cellular component	mitotic spindle
GO_0045171	Cellular component	intercellular bridge
GO_0005515	Molecular function	protein binding
GO_0008017	Molecular function	microtubule binding

Gene name	SKA1
Protein name	Alternative protein SKA1 Spindle and kinetochore-associated protein 1
Synonyms	C18orf24
Description	FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation . Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint . The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies . The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner . Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules . In the complex, it mediates the interaction with microtubules . .
Accessions	K7EPW0 ENST00000285116.8 [Q96BD8-1] ENST00000576078.2 ENST00000633940.1 [Q96BD8-2] ENST00000571318.5 ENST00000417656.6 [Q96BD8-2] L0R5C8 ENST00000494518.1 ENST00000398452.6 [Q96BD8-1] ENST00000488454.5 ENST00000571751.5 [Q96BD8-1] ENST00000616604.2 [Q96BD8-1] Q96BD8 K7EP61

SKA1 report