SIRT4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SIRT4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIRT4 at tissue level.

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0000820Biological processregulation of glutamine family amino acid metabolic process
GO_0006541Biological processglutamine metabolic process
GO_0046889Biological processpositive regulation of lipid biosynthetic process
GO_0046676Biological processnegative regulation of insulin secretion
GO_1903217Biological processnegative regulation of protein processing involved in protein targeting to mitochondrion
GO_0034983Biological processpeptidyl-lysine deacetylation
GO_0007005Biological processmitochondrion organization
GO_0046322Biological processnegative regulation of fatty acid oxidation
GO_0072350Biological processtricarboxylic acid metabolic process
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0040029Biological processepigenetic regulation of gene expression
GO_1904182Biological processregulation of pyruvate dehydrogenase activity
GO_0071456Biological processcellular response to hypoxia
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005759Cellular componentmitochondrial matrix
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0061690Molecular functionlipoamidase activity
GO_0106419Molecular functionNAD-dependent protein lipoamidase activity
GO_0003950Molecular functionNAD+ ADP-ribosyltransferase activity
GO_0106420Molecular functionNAD-dependent protein biotinidase activity
GO_0140803Molecular functionNAD+- protein-cysteine ADP-ribosyltransferase activity
GO_0004407Molecular functionhistone deacetylase activity
GO_0070403Molecular functionNAD+ binding
GO_0034979Molecular functionNAD-dependent protein lysine deacetylase activity
GO_0008270Molecular functionzinc ion binding
GO_1990404Molecular functionNAD+-protein ADP-ribosyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSIRT4
Protein nameNAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)
Sirtuin 4
SynonymsSIR2L4
DescriptionFUNCTION: Acts as a NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase . Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications . Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner . Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity . Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest . In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation . Acts as a tumor suppressor . Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Does not seem to deacetylate PC . Controls fatty acid oxidation by inhibiting PPARA transcriptional activation . Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels . Down-regulates insulin secretion . .

AccessionsF5H4X9
ENST00000202967.4
ENST00000536460.1
Q9Y6E7