SIRT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902553Biological processpositive regulation of catalase activity
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0006476Biological processprotein deacetylation
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_0006338Biological processchromatin remodeling
GO_0032024Biological processpositive regulation of insulin secretion
GO_2000304Biological processpositive regulation of ceramide biosynthetic process
GO_0034983Biological processpeptidyl-lysine deacetylation
GO_1901671Biological processpositive regulation of superoxide dismutase activity
GO_0009060Biological processaerobic respiration
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005759Cellular componentmitochondrial matrix
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0003950Molecular functionNAD+ ADP-ribosyltransferase activity
GO_0043565Molecular functionsequence-specific DNA binding
GO_0017136Molecular functionNAD-dependent histone deacetylase activity
GO_0070403Molecular functionNAD+ binding
GO_0034979Molecular functionNAD-dependent protein lysine deacetylase activity
GO_0008270Molecular functionzinc ion binding
GO_1990404Molecular functionNAD+-protein ADP-ribosyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSIRT3
Protein nameSirtuin 3
NAD-dependent protein deacetylase (EC 2.3.1.286)
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)
SynonymsSIR2L3
DescriptionFUNCTION: NAD-dependent protein deacetylase . Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues . Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO . Contributes to the regulation of the cellular energy metabolism . Important for regulating tissue-specific ATP levels . In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription . Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity). Regulates hepatic lipogenesis. Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately downregulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. .

FUNCTION: NAD-dependent protein deacetylase. .

AccessionsENST00000382743.9 [Q9NTG7-1]
E9PM52
ENST00000526854.5
ENST00000525237.1
ENST00000529382.5 [Q9NTG7-2]
ENST00000529055.5
ENST00000528469.1
E9PIT6
ENST00000532837.5
Q9NTG7
ENST00000525776.1
ENST00000525319.5
ENST00000524564.5
E9PNA0
ENST00000529937.1
E9PN58
E9PJS6
ENST00000530067.1
B7WNN4
E9PR48
ENST00000532956.5
E9PM75
E9PK80