SIK1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIK1 at tissue level.

III. Associated gene sets

GO_0010868Biological processnegative regulation of triglyceride biosynthetic process
GO_0002028Biological processregulation of sodium ion transport
GO_0045721Biological processnegative regulation of gluconeogenesis
GO_0055007Biological processcardiac muscle cell differentiation
GO_0043276Biological processanoikis
GO_0010830Biological processregulation of myotube differentiation
GO_0032792Biological processnegative regulation of CREB transcription factor activity
GO_0035556Biological processintracellular signal transduction
GO_0045595Biological processregulation of cell differentiation
GO_0007346Biological processregulation of mitotic cell cycle
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_2000210Biological processpositive regulation of anoikis
GO_0048511Biological processrhythmic process
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0071889Molecular function14-3-3 protein binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0008140Molecular functioncAMP response element binding protein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameSIK1
Protein nameSerine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)
Salt inducible kinase 1
SynonymsSNF1LK
SIK
DescriptionFUNCTION: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling . Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). .

AccessionsENST00000270162.8
P57059
A0A2R8Y6E4
ENST00000644750.1