SIDT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000902Biological processcell morphogenesis
GO_0044342Biological processtype B pancreatic cell proliferation
GO_0050658Biological processRNA transport
GO_0061178Biological processregulation of insulin secretion involved in cellular response to glucose stimulus
GO_0009749Biological processresponse to glucose
GO_0003323Biological processtype B pancreatic cell development
GO_0042593Biological processglucose homeostasis
GO_0006401Biological processRNA catabolic process
GO_0005764Cellular componentlysosome
GO_0005765Cellular componentlysosomal membrane
GO_0005886Cellular componentplasma membrane
GO_0003677Molecular functionDNA binding
GO_0035612Molecular functionAP-2 adaptor complex binding
GO_0035650Molecular functionAP-1 adaptor complex binding
GO_0051032Molecular functionnucleic acid transmembrane transporter activity
GO_0003725Molecular functiondouble-stranded RNA binding
GO_0051033Molecular functionRNA transmembrane transporter activity

IV. Literature review

[source]
Gene nameSIDT2
Protein nameSID1 transmembrane family member 2 (SID1 transmembrane family, member 2, isoform CRA_k)
SIDT2 protein
SID1 transmembrane family member 2
SID1 transmembrane family member 2 (SID1 transmembrane family, member 2, isoform CRA_a)
SynonymsPSEC0072
UNQ685/PRO1325
hCG_2039721
CGI-40
DescriptionFUNCTION: Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded . Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis . In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity). .

AccessionsG3V172
ENST00000532062.1
ENST00000532960.5
ENST00000324225.9 [Q8NBJ9-1]
F5H8L4
ENST00000525478.5
E9PPN9
ENST00000278951.11
ENST00000531353.1
E9PME7
C9JBG5
L7X6U2
ENST00000628876.2
Q8NBJ9
Q24JR2
Q1RMF0
H0YEI3
E9PMC3
ENST00000524842.5
ENST00000431081.6