I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 4 studies | 36% ± 11% | |
| interneuron | 4 studies | 34% ± 15% | |
| glutamatergic neuron | 3 studies | 26% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 4 studies | 36% ± 11% | |
| interneuron | 4 studies | 34% ± 15% | |
| glutamatergic neuron | 3 studies | 26% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 23% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 69% | 44.05 | 179 / 258 | 49% | 1.25 | 113 / 230 |
| brain | 93% | 341.39 | 2444 / 2642 | 16% | 0.43 | 114 / 705 |
| kidney | 76% | 107.16 | 68 / 89 | 1% | 0.04 | 10 / 901 |
| ovary | 7% | 3.71 | 13 / 180 | 55% | 2.19 | 238 / 430 |
| uterus | 20% | 45.65 | 34 / 170 | 10% | 0.37 | 48 / 459 |
| lung | 15% | 11.63 | 87 / 578 | 3% | 0.06 | 31 / 1155 |
| spleen | 17% | 7.70 | 42 / 241 | 0% | 0 | 0 / 0 |
| intestine | 16% | 11.31 | 158 / 966 | 0% | 0 | 0 / 527 |
| breast | 9% | 3.66 | 43 / 459 | 1% | 0.14 | 12 / 1118 |
| adipose | 10% | 6.28 | 118 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 8% | 3.14 | 28 / 359 | 1% | 0.02 | 3 / 286 |
| skin | 8% | 3.00 | 137 / 1809 | 1% | 0.02 | 5 / 472 |
| prostate | 7% | 2.89 | 18 / 245 | 0% | 0.01 | 2 / 502 |
| bladder | 5% | 3.52 | 1 / 21 | 1% | 0.04 | 6 / 504 |
| thymus | 4% | 1.81 | 28 / 653 | 0% | 0.00 | 1 / 605 |
| pancreas | 0% | 0 | 0 / 328 | 2% | 0.04 | 4 / 178 |
| muscle | 2% | 0.96 | 18 / 803 | 0% | 0 | 0 / 0 |
| esophagus | 1% | 0.62 | 20 / 1445 | 1% | 0.01 | 1 / 183 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.03 | 1 / 80 |
| heart | 1% | 0.21 | 5 / 861 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 0% | 0.01 | 2 / 406 |
| blood vessel | 0% | 0.24 | 6 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.17 | 4 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1903215 | Biological process | negative regulation of protein targeting to mitochondrion |
| GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| GO_0031647 | Biological process | regulation of protein stability |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0031624 | Molecular function | ubiquitin conjugating enzyme binding |
| Gene name | SIAH3 |
| Protein name | Seven in absentia homolog 3 (Siah-3) |
| Synonyms | |
| Description | FUNCTION: Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria. . |
| Accessions | ENST00000400405.4 Q8IW03 |
