SHISA7 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	5 studies	28% ± 8%	Explore
GABAergic neuron	3 studies	35% ± 11%	Explore
glutamatergic neuron	3 studies	46% ± 16%	Explore

Name	Number of supported studies	Average coverage
brain	4 studies	33% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	3992.21	2639 / 2642	93%	22.84	656 / 705
adrenal gland	4%	23.00	11 / 258	30%	2.38	69 / 230
pancreas	0%	0	0 / 328	7%	0.66	12 / 178
skin	0%	0.16	1 / 1809	4%	0.10	17 / 472
uterus	0%	0	0 / 170	3%	0.10	14 / 459
esophagus	0%	0.23	1 / 1445	2%	0.05	4 / 183
tonsil	0%	0	0 / 0	2%	0.09	1 / 45
lung	0%	0	0 / 578	1%	0.03	17 / 1155
eye	0%	0	0 / 0	1%	0.02	1 / 80
intestine	0%	1.32	4 / 966	1%	0.04	4 / 527
peripheral blood	1%	3.15	8 / 929	0%	0	0 / 0
stomach	0%	0	0 / 359	1%	0.01	2 / 286
bladder	0%	0	0 / 21	1%	0.01	3 / 504
breast	0%	0	0 / 459	1%	0.07	6 / 1118
ovary	0%	0	0 / 180	0%	0.00	1 / 430
kidney	0%	0	0 / 89	0%	0.03	2 / 901
adipose	0%	0.51	2 / 1204	0%	0	0 / 0
thymus	0%	0	0 / 653	0%	0.00	1 / 605
abdomen	0%	0	0 / 0	0%	0	0 / 0
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0	0 / 406
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
prostate	0%	0	0 / 245	0%	0	0 / 502
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007613	Biological process	memory
GO_0007214	Biological process	gamma-aminobutyric acid signaling pathway
GO_1904717	Biological process	regulation of AMPA glutamate receptor clustering
GO_0106040	Biological process	regulation of GABA-A receptor activity
GO_0048172	Biological process	regulation of short-term neuronal synaptic plasticity
GO_1900273	Biological process	positive regulation of long-term synaptic potentiation
GO_2000311	Biological process	regulation of AMPA receptor activity
GO_0097112	Biological process	gamma-aminobutyric acid receptor clustering
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0098985	Cellular component	asymmetric, glutamatergic, excitatory synapse
GO_0032281	Cellular component	AMPA glutamate receptor complex
GO_0014069	Cellular component	postsynaptic density
GO_0032591	Cellular component	dendritic spine membrane
GO_0045211	Cellular component	postsynaptic membrane
GO_0035255	Molecular function	ionotropic glutamate receptor binding
GO_0050811	Molecular function	GABA receptor binding

Gene name	SHISA7
Protein name	Protein shisa-7 (Cystine-knot AMPAR modulating protein of 59 kDa) (CKAMP59) (GABA(A) receptor auxiliary subunit Shisa7) (Protein shisa-6-like) Shisa family member 7
Synonyms
Description	FUNCTION: Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses. .
Accessions	ENST00000416792.2 A6NL88 H7C1N4 ENST00000376325.10

SHISA7 report