SHISA4 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
astrocyte	3 studies	24% ± 6%	Explore
fibroblast	3 studies	43% ± 25%	Explore
oligodendrocyte	3 studies	21% ± 5%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
brain	3 studies	20% ± 1%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	5166.76	2641 / 2642	100%	172.06	703 / 705
adrenal gland	100%	3631.49	258 / 258	97%	54.74	223 / 230
ovary	98%	1313.47	177 / 180	95%	37.61	410 / 430
prostate	93%	1191.19	228 / 245	99%	30.25	495 / 502
thymus	99%	1751.57	647 / 653	86%	52.41	523 / 605
breast	85%	773.98	388 / 459	88%	30.09	987 / 1118
bladder	95%	1071.57	20 / 21	69%	18.96	350 / 504
uterus	95%	1131.09	162 / 170	54%	16.77	247 / 459
lung	68%	604.64	393 / 578	79%	24.34	916 / 1155
skin	43%	511.18	785 / 1809	98%	70.04	461 / 472
kidney	57%	515.94	51 / 89	67%	13.49	605 / 901
esophagus	62%	826.18	890 / 1445	51%	10.59	93 / 183
pancreas	8%	58.92	26 / 328	92%	24.65	164 / 178
muscle	100%	10110.11	802 / 803	0%	0	0 / 0
blood vessel	99%	2684.56	1327 / 1335	0%	0	0 / 0
heart	96%	3426.35	825 / 861	0%	0	0 / 0
intestine	62%	651.61	601 / 966	33%	6.55	176 / 527
eye	0%	0	0 / 0	94%	25.14	75 / 80
stomach	44%	535.21	157 / 359	42%	8.60	121 / 286
adipose	79%	756.42	957 / 1204	0%	0	0 / 0
liver	2%	14.99	4 / 226	68%	24.34	275 / 406
tonsil	0%	0	0 / 0	16%	3.89	7 / 45
peripheral blood	12%	112.38	108 / 929	0%	0	0 / 0
spleen	11%	76.49	26 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	3%	0.39	1 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1