SHBG | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SHBG at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	939.44	226 / 226	90%	36.78	364 / 406
brain	99%	44.95	2610 / 2642	89%	1.90	629 / 705
thymus	100%	45.39	651 / 653	39%	0.64	235 / 605
adrenal gland	100%	73.75	258 / 258	33%	0.62	75 / 230
kidney	100%	106.29	89 / 89	30%	0.60	274 / 901
prostate	98%	31.50	240 / 245	26%	0.41	129 / 502
ovary	99%	38.52	178 / 180	20%	0.35	86 / 430
uterus	98%	30.91	166 / 170	13%	0.19	58 / 459
breast	94%	23.61	433 / 459	4%	0.07	48 / 1118
adipose	97%	32.00	1172 / 1204	0%	0	0 / 0
bladder	90%	17.10	19 / 21	7%	0.10	34 / 504
spleen	97%	23.88	233 / 241	0%	0	0 / 0
stomach	84%	13.66	303 / 359	12%	0.32	33 / 286
lung	89%	17.56	516 / 578	5%	0.11	58 / 1155
intestine	89%	39.95	855 / 966	4%	0.27	23 / 527
esophagus	82%	14.39	1192 / 1445	9%	0.24	17 / 183
muscle	91%	22.02	728 / 803	0%	0	0 / 0
skin	68%	11.89	1237 / 1809	22%	0.35	104 / 472
heart	88%	17.68	761 / 861	0%	0	0 / 0
pancreas	81%	12.08	265 / 328	4%	0.07	7 / 178
eye	0%	0	0 / 0	61%	1.04	49 / 80
blood vessel	57%	7.93	763 / 1335	0%	0	0 / 0
peripheral blood	13%	1.84	121 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	7%	0.08	3 / 45
lymph node	0%	0	0 / 0	3%	0.11	1 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

IV. Literature review

[source]

Gene name	SHBG
Protein name	Sex hormone binding globulin Sex hormone-binding globulin (Sex steroid-binding protein) (Testis-specific androgen-binding protein) Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin)
Synonyms	hCG_42018
Description	FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. . FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. . FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. . FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. . FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. . FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. . FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. . FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. . FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. . FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. . FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. . FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. .
Accessions	B0FWH5 ENST00000575903.5 [P04278-5] B0FWH6 ENST00000576152.1 ENST00000575618.5 I3L4B9 I3L1J1 ENST00000572262.5 P04278 ENST00000416273.7 [P04278-3] ENST00000574539.5 [P04278-2] ENST00000576478.5 B0FWH7 I3L0M1 ENST00000441599.6 [P04278-4] ENST00000576830.5 ENST00000575314.5 ENST00000571153.5 ENST00000570547.5 ENST00000380450.9 [P04278-1] ENST00000576728.5 B0FWH2 I3L1G4 ENST00000572182.5 I3L4D0 ENST00000570527.5 ENST00000575729.5 I3L2X4 ENST00000570353.5 ENST00000340624.9 I3L2F1 I3L145 A0A0C4DGN2 I3L1C1 B0FWH8

GO_0070062	Cellular component	extracellular exosome
GO_0005576	Cellular component	extracellular region
GO_0005497	Molecular function	androgen binding
GO_0005515	Molecular function	protein binding
GO_0005496	Molecular function	steroid binding

SHBG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review