SH3BP4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SH3BP4 at tissue level.

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0034260Biological processnegative regulation of GTPase activity
GO_0006897Biological processendocytosis
GO_0032007Biological processnegative regulation of TOR signaling
GO_0061462Biological processprotein localization to lysosome
GO_0010508Biological processpositive regulation of autophagy
GO_0071230Biological processcellular response to amino acid stimulus
GO_0050790Biological processregulation of catalytic activity
GO_0043090Biological processamino acid import
GO_0030308Biological processnegative regulation of cell growth
GO_0070062Cellular componentextracellular exosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005737Cellular componentcytoplasm
GO_0005905Cellular componentclathrin-coated pit
GO_0005634Cellular componentnucleus
GO_0005092Molecular functionGDP-dissociation inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSH3BP4
Protein nameSH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein)
SH3 domain binding protein 4
SynonymsBOG25
EHB10
TTP
DescriptionFUNCTION: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. .

AccessionsENST00000444916.5
ENST00000344528.8 [Q9P0V3-1]
Q9P0V3
C9JRG1
C9JWW6
ENST00000392011.7 [Q9P0V3-1]
C9JF25
C9JED2
ENST00000409212.5 [Q9P0V3-1]
ENST00000446904.5
ENST00000416021.5
ENST00000454947.1