SGO2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SGO2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SGO2 at tissue level.

III. Associated gene sets

GO_0051321Biological processmeiotic cell cycle
GO_0051301Biological processcell division
GO_0007059Biological processchromosome segregation
GO_0051177Biological processmeiotic sister chromatid cohesion
GO_0000775Cellular componentchromosome, centromeric region
GO_0000776Cellular componentkinetochore
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0030892Cellular componentmitotic cohesin complex
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSGO2
Protein nameShugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin)
Shugoshin 2
SynonymsSGOL2
DescriptionFUNCTION: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. .

AccessionsC9JW92
ENST00000357799.9 [Q562F6-1]
ENST00000409203.3 [Q562F6-3]
Q562F6
ENST00000418045.5