SGO1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SGO1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SGO1 at tissue level.

III. Associated gene sets

GO_0071962Biological processmitotic sister chromatid cohesion, centromeric
GO_0045132Biological processmeiotic chromosome segregation
GO_0008608Biological processattachment of spindle microtubules to kinetochore
GO_0051301Biological processcell division
GO_0010457Biological processcentriole-centriole cohesion
GO_0007059Biological processchromosome segregation
GO_0000775Cellular componentchromosome, centromeric region
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0000779Cellular componentcondensed chromosome, centromeric region
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000922Cellular componentspindle pole
GO_0019900Molecular functionkinase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSGO1
Protein nameShugoshin 1
Shugoshin-like 1 isoform P1
Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1)
Shugoshin-like 1 (S. pombe), isoform CRA_a (Shugoshin-like 1 isoform A1)
SynonymsSGOL1
hCG_1648559
DescriptionFUNCTION: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. .

AccessionsENST00000419233.6 [Q5FBB7-2]
ENST00000306698.6 [Q5FBB7-3]
ENST00000417364.1 [Q5FBB7-4]
ENST00000442720.5 [Q5FBB7-5]
Q5FBB7
ENST00000443724.5 [Q5FBB7-7]
ENST00000452020.5 [Q5FBB7-3]
ENST00000456624.1
ENST00000263753.8 [Q5FBB7-1]
E9RFS7
F8WB17
ENST00000412997.6 [Q5FBB7-6]
ENST00000421451.5 [Q5FBB7-1]
ENST00000425061.5 [Q5FBB7-2]
B5BUA4
ENST00000437051.5 [Q5FBB7-4]