I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| adipocyte | 4 studies | 27% ± 8% | |
| oligodendrocyte | 3 studies | 23% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipocyte | 4 studies | 27% ± 8% | |
| oligodendrocyte | 3 studies | 23% ± 5% |
Insufficient scRNA-seq data for expression of SGK2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 4476.14 | 226 / 226 | 99% | 19.66 | 401 / 406 |
| kidney | 100% | 4539.52 | 89 / 89 | 96% | 14.69 | 868 / 901 |
| pancreas | 100% | 1079.75 | 328 / 328 | 80% | 5.59 | 143 / 178 |
| intestine | 87% | 1481.30 | 842 / 966 | 86% | 11.67 | 455 / 527 |
| stomach | 90% | 1268.04 | 322 / 359 | 83% | 11.63 | 238 / 286 |
| bladder | 86% | 385.52 | 18 / 21 | 51% | 7.21 | 259 / 504 |
| brain | 90% | 414.95 | 2373 / 2642 | 45% | 2.13 | 318 / 705 |
| ovary | 98% | 610.54 | 177 / 180 | 21% | 0.93 | 89 / 430 |
| breast | 98% | 667.34 | 451 / 459 | 9% | 0.33 | 106 / 1118 |
| uterus | 88% | 309.99 | 150 / 170 | 17% | 1.72 | 77 / 459 |
| prostate | 92% | 285.69 | 225 / 245 | 9% | 0.50 | 43 / 502 |
| adipose | 96% | 698.29 | 1160 / 1204 | 0% | 0 | 0 / 0 |
| esophagus | 44% | 74.62 | 640 / 1445 | 46% | 7.49 | 84 / 183 |
| thymus | 84% | 182.90 | 550 / 653 | 5% | 0.13 | 28 / 605 |
| blood vessel | 77% | 198.13 | 1023 / 1335 | 0% | 0 | 0 / 0 |
| lung | 49% | 74.02 | 283 / 578 | 27% | 1.88 | 315 / 1155 |
| skin | 71% | 294.81 | 1289 / 1809 | 3% | 0.15 | 14 / 472 |
| adrenal gland | 61% | 104.42 | 157 / 258 | 4% | 0.47 | 9 / 230 |
| spleen | 58% | 100.08 | 140 / 241 | 0% | 0 | 0 / 0 |
| heart | 15% | 31.81 | 133 / 861 | 0% | 0 | 0 / 0 |
| muscle | 1% | 2.09 | 12 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 3.17 | 9 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032411 | Biological process | positive regulation of transporter activity |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0001558 | Biological process | regulation of cell growth |
| GO_0042127 | Biological process | regulation of cell population proliferation |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0017080 | Molecular function | sodium channel regulator activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0015459 | Molecular function | potassium channel regulator activity |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | SGK2 |
| Protein name | Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2) Serum/glucocorticoid regulated kinase 2 |
| Synonyms | |
| Description | FUNCTION: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. . |
| Accessions | X6R8H3 ENST00000341458.10 [Q9HBY8-2] A0A0G2JNI2 ENST00000647834.1 ENST00000496343.6 A0A3B3IRX6 A0A3B3IT40 A0A3B3IRL0 ENST00000373100.7 [Q9HBY8-2] Q5H8Y5 ENST00000423407.7 [Q9HBY8-2] ENST00000412111.6 A0A3B3IUG0 F2Z3C8 ENST00000617268.1 Q9HBY8 ENST00000373077.5 ENST00000485914.2 ENST00000648083.1 ENST00000426287.3 [Q9HBY8-2] ENST00000648530.1 |
